Congenital disorders of glycosylation (CDG) are one group among the disorders of
glycosylation. The latter comprise defects associated with hypoglycosylation but also defects …

Congenital disorders of glycosylation (CDG) are a group of clinically heterogeneous
disorders characterized by defects in the synthesis of glycans and their attachment to …

Copper is an essential metal required for many metalloproteins' function. A fraction of dietary
copper (average 2–5 mg/day) is absorbed by enterocytes in the duodenum and proximal …

Host dependency factors that are required for influenza A virus infection may serve as
therapeutic targets as the virus is less likely to bypass them under drug-mediated selection …

Recent studies using cell type–specific knockout mouse models have improved our
understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA …

Background and Aims Hepatocellular carcinoma (HCC) is associated with high malignancy
rates. Recently, a known deacetylase silent information regulator 1 (SIRT1) was discovered …

Conclusions In a large cohort of DAA‐treated patients with cirrhotic HCV, GRS was
associated with de novo HCC independently of classical risk factors, including liver disease …

The V-ATPase is the main regulator of intra-organellar acidification. Assembly of this
complex has extensively been studied in yeast, while limited knowledge exists for man. We …

Congenital disorders of glycosylation (CDG) are a rapidly growing family of genetic diseases
caused by defects in glycosylation. Nearly 100 CDG types are known so far. Patients present …

Defects of the V-type proton (H+) ATPase (V-ATPase) impair acidification and intracellular
trafficking of membrane-enclosed compartments, including secretory granules, endosomes …