To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated
by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by …

Nitric oxide (NO) is an essential signaling molecule in biological systems. In mammals, the
diatomic gas is critical to the cyclic guanosine monophosphate (cGMP) pathway as it …

As a chemical transmitter in the mammalian central nervous system, nitric oxide (NO) is still
thought a bit of an oddity, yet this role extends back to the beginnings of the evolution of the …

Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric
oxide (NO). Impaired bioavailability and/or responsiveness to endogenous NO has been …

The use of nitroglycerin in the treatment of angina pectoris began not long after its original
synthesis in 1847. Since then, the discovery of nitric oxide as a biological effector and better …

Nitric oxide (NO) in oxygen-containing aqueous solution has a short half-life that is often
attributed to a rapid oxidation to both NO2-and NO3-. The chemical fate of NO in aqueous …

In retrospect, basic research in the fields of nitric oxide (NO) and cyclic guanosine
monophosphate (cGMP) during the past two decades appears to have followed a logical …

In retrospect, basic research in the fields of NO and cyclic GMP during thev past two
decades appears to have followed a logical course beginning with the findings that NO and …

In this review, we outline the current knowledge on the regulation of nitric oxide (NO)-
sensitive guanylyl cyclase (GC). Besides NO, the physiological activator that binds to the …

Nitric oxide first captured the interest of biologists when this inorganic molecule was found to
activate cytosolic guanylate cyclase and stimulate cyclic guanosine monophosphate (GMP) …