Multiplicity Considerations in Clinical Trials | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …

Background The cancer-cell–killing property of atezolizumab may be enhanced by the
blockade of vascular endothelial growth factor–mediated immunosuppression with …

Background Patients with acute myocardial infarction (MI) are at risk for developing heart
failure (HF) and subsequently are at an increased risk of mortality. Sodium-glucose …

In this article we review recent advances in-value-based multiple test procedures (MTPs).
We begin with a brief review of the basic tests of Bonferroni and Simes. Standard stepwise …

Acute myocardial infarction (MI) patients remain at high risk for recurrent events. Cholesterol
efflux, mediated by apolipoprotein AI, removes excess cholesterol from atherosclerotic …

Major depressive disorder (MDD) is a mental health disorder that can cause disability and
functional impairment that standard-of-care (SOC) antidepressant therapies (ADTs) can take …

Background Preterm delivery remains the leading cause of perinatal mortality. Risk factors
and biomarkers have traditionally failed to identify the majority of preterm deliveries …

This tutorial discusses important statistical problems arising in clinical trials with multiple
clinical objectives based on different clinical variables, evaluation of several doses or …

Purpose Meibomian gland dysfunction (MGD) is a chronic progressive disease with
downstream effects on ocular signs and symptoms. AZR-MD-001 is a selenium sulfide …

Objective To test a scalable health system intervention to improve long term adherence to
secondary prevention treatments among patients who have had a recent myocardial …