Using machine learning to impact on long-term clinical care: principles, challenges, and practicalities
The rise of machine learning in healthcare has significant implications for paediatrics. Long-
term conditions with significant disease heterogeneity comprise large portions of the routine …
term conditions with significant disease heterogeneity comprise large portions of the routine …
Emerging biomarkers for prediction and early diagnosis of necrotizing enterocolitis in the era of metabolomics and proteomics
Necrotizing Enterocolitis (NEC) is a catastrophic disease affecting predominantly premature
infants and is characterized by high mortality and serious long-term consequences …
infants and is characterized by high mortality and serious long-term consequences …
Longitudinal development of the gut microbiome and metabolome in preterm neonates with late onset sepsis and healthy controls
Background Late onset sepsis (LOS) in preterm infants is associated with considerable
morbidity and mortality. While studies have implicated gut bacteria in the aetiology of the …
morbidity and mortality. While studies have implicated gut bacteria in the aetiology of the …
Temporal bacterial and metabolic development of the preterm gut reveals specific signatures in health and disease
Background The preterm microbiome is crucial to gut health and may contribute to
necrotising enterocolitis (NEC), which represents the most significant pathology affecting …
necrotising enterocolitis (NEC), which represents the most significant pathology affecting …
Effect of an exclusive human milk diet on the gut microbiome in preterm infants: a randomized clinical trial
Importance The effect of using an exclusive human milk diet compared with one that uses
bovine products in preterm infants is uncertain, but some studies demonstrate lower rates of …
bovine products in preterm infants is uncertain, but some studies demonstrate lower rates of …
Necrotizing enterocolitis: The intestinal microbiome, metabolome and inflammatory mediators
Necrotizing enterocolitis (NEC) is a disease of preterm infants and associated with
significant mortality and morbidity. Although the pathogenesis of NEC is not clear, microbial …
significant mortality and morbidity. Although the pathogenesis of NEC is not clear, microbial …
When a neonate is born, so is a microbiota
A Coscia, F Bardanzellu, E Caboni, V Fanos… - Life, 2021 - mdpi.com
In recent years, the role of human microbiota as a short-and long-term health promoter and
modulator has been affirmed and progressively strengthened. In the course of one's life …
modulator has been affirmed and progressively strengthened. In the course of one's life …
The metabolome and the gut microbiota for the prediction of necrotizing enterocolitis and spontaneous intestinal perforation: a systematic review
L Moschino, G Verlato, M Duci, ME Cavicchiolo… - Nutrients, 2022 - mdpi.com
Necrotizing enterocolitis (NEC) is the most devastating gastrointestinal emergency in
preterm neonates. Research on early predictive biomarkers is fundamental. This is a …
preterm neonates. Research on early predictive biomarkers is fundamental. This is a …
Biomarkers for the diagnosis of neonatal sepsis and necrotizing enterocolitis: Clinical practice guidelines
M Gilfillan, V Bhandari - Early human development, 2017 - Elsevier
Sepsis and necrotizing enterocolitis are major contributors to morbidity and mortality in
neonates, especially in those born preterm. While therapeutic interventions are available for …
neonates, especially in those born preterm. While therapeutic interventions are available for …
Metabolomics in NEC: an updated review
A Bosco, C Piu, ME Picciau, R Pintus, V Fanos, A Dessì - Metabolites, 2023 - mdpi.com
Necrotizing enterocolitis (NEC) represents the most common and lethal acute
gastrointestinal emergency of newborns, mainly affecting those born prematurely. It can lead …
gastrointestinal emergency of newborns, mainly affecting those born prematurely. It can lead …