Is minor salivary gland biopsy still mandatory in Sjogren's syndrome? Does seronegative Sjogren's syndrome exist?

C Baldini, O Berardicurti, R Giacomelli… - Autoimmunity …, 2024 - Elsevier
Sjӧgren's disease (SjD) is a systemic autoimmune disorder characterized by the chronic
inflammation and dysfunction of exocrine glands, mainly salivary glands, causing dryness of …

Can salivary gland ultrasonography replace salivary gland biopsy in the diagnosis of Sjögren's syndrome?

K Delli, MS van Ginkel, A Vissink, AJ Stel… - Clinical and …, 2022 - research.rug.nl
Ultrasound is a promising diagnostic method when it comes to assessing the involvement of
major salivary glands in patients with primary Sjögren's syndrome (pSS). A matter of debate …

Serum and Tissue Biomarkers Associated With Composite of Relevant Endpoints for Sjögren Syndrome (CRESS) and Sjögren Tool for Assessing Response (STAR) …

E Pontarini, E Sciacca, F Chowdhury… - Arthritis & …, 2024 - Wiley Online Library
Objective This study aimed to identify peripheral and salivary gland (SG) biomarkers of
response/resistance to B cell depletion based on the novel concise Composite of Relevant …

Histopathology, salivary flow and ultrasonography of the parotid gland: three complementary measurements in primary Sjögren's syndrome

E Mossel, MS van Ginkel, EA Haacke, S Arends… - …, 2022 - academic.oup.com
Objective The involvement of salivary glands in primary SS (pSS) can be assessed in
different ways: histopathology, salivary flow and ultrasonography. To understand the relative …

[PDF][PDF] One year in review 2021: Sjögren's syndrome

G Cafaro, R Bursi, LG Chatzis, G Fulvio… - Clin Exp …, 2021 - clinexprheumatol.org
Sjögren's syndrome (SS) is a multifactorial systemic autoimmune disease of unknown
aetiology characterised by a wide spectrum of different clinical manifestations and scattered …

recent advances of salivary gland biopsy in sjögren's syndrome

R Liao, HT Yang, H Li, LX Liu, K Li, JJ Li, J Liang… - Frontiers in …, 2022 - frontiersin.org
Sjögren's syndrome (SS) is a chronic, systemic, inflammatory autoimmune disease
characterized by lymphocyte proliferation and progressive damage to exocrine glands. The …

Cellular and molecular diversity in Sjogren's syndrome salivary glands: Towards a better definition of disease subsets

E Pontarini, R Coleby, M Bombardieri - Seminars in Immunology, 2021 - Elsevier
Primary Sjögren's syndrome (pSS) is a highly heterogeneous disease in terms of clinical
presentation ranging from a mild disease localised to the salivary and lacrimal glands, to …

Multi-Stain Self-Attention Graph Multiple Instance Learning Pipeline for Histopathology Whole Slide Images

A Gallagher-Syed, L Rossi, F Rivellese… - arXiv preprint arXiv …, 2023 - arxiv.org
Whole Slide Images (WSIs) present a challenging computer vision task due to their gigapixel
size and presence of numerous artefacts. Yet they are a valuable resource for patient …

Digital image analysis of intraepithelial B-lymphocytes to assess lymphoepithelial lesions in salivary glands of Sjögren's syndrome patients

MS van Ginkel, T van der Sluis, MLC Bulthuis… - …, 2023 - academic.oup.com
Objective Salivary glands of primary SS (pSS) patients characteristically harbour periductal
infiltrates, in which lymphoepithelial lesions (LELs) can develop. LELs are composed of …

[PDF][PDF] Total area of inflammatory infiltrate and percentage of inflammatory infiltrate identify different clinical-serological subsets of primary Sjögren's syndrome better …

V Donati, F Ferro, G Governato, G Fulvio… - Clin Exp …, 2020 - clinexprheumatol.org
Objective. Recently, the total area of the inflammatory infiltrate and the percentage of
inflammatory infiltrate have been proposed as novel histopathological parameters to …