Chlamydia are obligate intracellular bacteria, characterized by a unique biphasic
developmental cycle. Specific interactions with the host cell are crucial for the bacteria's …

Abstract 3β-Hydroxysterol Δ 24-reductase (DHCR24) catalyzes the conversion of
desmosterol to cholesterol. This ultimate step of cholesterol biosynthesis appears to be …

This perspective addresses recent advances in lipid transport across the Gram-negative
inner and outer membranes. While we include a summary of previously existing literature …

Sepsis, a complex and dynamic syndrome resulting from microbial invasion and immune
system dysregulation, is associated with an increased mortality, reaching up to 35 …

Successful macrophage colonization by Coxiella burnetii, the cause of human Q fever,
requires pathogen-directed biogenesis of a large, growth-permissive parasitophorous …

Cholesterol is a multifunctional lipid that plays important metabolic and structural roles in the
eukaryotic cell. Despite having diverse lifestyles, the obligate intracellular bacterial …

We sought a new approach to treating infections by intracellular bacteria, namely, by altering
host cell functions that support their growth. We screened a library of 640 Food and Drug …

Summary “Lipids” is the inclusive name for a complex group of molecules composed
predominantly of carbon, hydrogen, and oxygen (also nitrogen and phosphorus) that are …

Coxiella burnetii replicates in an acidified lysosome-derived vacuole. Biogenesis of the
Coxiella-containing vacuole (CCV) requires bacterial effector proteins delivered into host …

Lipid droplets (LDs) are cytosolic lipid storage organelles that are important for cellular lipid
metabolism, energy homeostasis, cell signaling, and inflammation. Several bacterial, viral …