Protein misfolding and amyloid deposition are associated with numerous diseases. The
detailed characterization of the proteospecies mediating cell death remains elusive owing to …

Glycosaminoglycans (GAGs) are long and unbranched anionic heteropolysaccharides that
have been associated with virtually all amyloid deposits. Soluble sulfated GAGs are known …

Islet amyloid polypeptide (IAPP), also known as amylin, is a polypeptide hormone co-
secreted with insulin by pancreatic β-cells. In general, IAPP is soluble and lacks a defined …

Fluorescent modification of proteins of interest (POI) in living cells is desired to study their
behaviour and functions in their natural environment. In a perfect setting it should be easy to …

The islet amyloid polypeptide (IAPP) is a 37-residue aggregation-prone peptide hormone
whose deposition as insoluble fibrils in the islets of Langerhans is associated with type II …

Amyloids are polypeptide supramolecular assemblies that have been historically associated
with numerous pathologies. Nonetheless, recent studies have identified many amyloid …

The deposition of insoluble proteinaceous aggregates in the form of amyloid fibrils within the
extracellular space of tissues is associated with numerous diseases. The development of …

Aggregation of polypeptides and proteins is commonly associated with human and other
vertebrate diseases. For example, amyloid plaques consisting of amyloid-β proteins are …

The polypeptide amylin is responsible for islet amyloid in type 2 diabetes, a process which
contributes to β-cell death in the disease. The role of the N-terminal region of amylin in …

Biologics such as peptides and proteins possess a number of attractive attributes that make
them particularly valuable as therapeutics, including their high activity, high specificity, and …