Affibody molecules are small (58 amino acids) engineered scaffold proteins that can be
selected to bind to a large variety of proteins with a high affinity. Their small size and high …

Pretargeted radioimmunodiagnosis and radioimmunotherapy aim to efficiently combine
antitumor antibodies and medicinal radioisotopes for high-contrast imaging and high …

The use of radiolabelled antibodies was proposed in 1970s for staging of malignant
tumours. Intensive research established chemistry for radiolabelling of proteins and …

Purpose A novel HER2 affibody-based molecular probe,[18F] AlF-RESCA-HER2-BCH, was
developed for reducing renal uptake, evaluated, and compared with [18F] AlF-NOTA-HER2 …

Introduction Bifunctional chelators have been shown to impact the biodistribution of
monoclonal antibody (mAb)-based imaging agents. Recently, radiolabeled 1, 4, 7 …

The worldwide utilization of 68Ga‐radionuclide for the fundamental research and clinical
applications is growing exponentially. A broad range of 68Ga‐based imaging agents has …

Epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor,
which is overexpressed in many types of cancer. The use of EGFR-targeting monoclonal …

Affibody molecules constitute a new class of probes for radionuclide tumor targeting. The
small size of Affibody molecules is favorable for rapid localization in tumors and clearance …

The αvβ3-integrin addressing cyclic pentapeptide cyclo (RGDfK) was conjugated to NOPO,
1, 4, 7-triazacyclononane-1, 4-bis [methylene (hydroxymethyl) phosphinic acid]-7 …

Platelet-derived growth factor receptor β (PDGFRβ) is a transmembrane tyrosine kinase
receptor involved, for example, in angiogenesis. Overexpression and excessive signaling of …