Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial
JD Gunst, MH Pahus, M Rosás-Umbert, IN Lu… - Nature medicine, 2022 - nature.com
Attempts to reduce the human immunodeficiency virus type 1 (HIV-1) reservoir and induce
antiretroviral therapy (ART)-free virologic control have largely been unsuccessful. In this …
antiretroviral therapy (ART)-free virologic control have largely been unsuccessful. In this …
Addressing an HIV cure in LMIC
HIV-1 persists in infected individuals despite years of antiretroviral therapy (ART), due to the
formation of a stable and long-lived latent viral reservoir. Early ART can reduce the latent …
formation of a stable and long-lived latent viral reservoir. Early ART can reduce the latent …
Cryptococcal immune reconstitution inflammatory syndrome: from blood and cerebrospinal fluid biomarkers to treatment approaches
VMS Brienze, JC André, E Liso, I Vlasova-St. Louis - Life, 2021 - mdpi.com
Immune reconstitution inflammatory syndrome (IRIS) presents as an exaggerated immune
reaction that occurs during dysregulated immune restoration in immunocompromised …
reaction that occurs during dysregulated immune restoration in immunocompromised …
Memory CD4+ T cells that co-express PD1 and CTLA4 have reduced response to activating stimuli facilitating HIV latency
TA Rasmussen, JM Zerbato, A Rhodes, C Tumpach… - Cell Reports …, 2022 - cell.com
Summary Programmed cell death 1 (PD1) and cytotoxic T lymphocyte-associated protein 4
(CTLA4) suppress CD4+ T cell activation and may promote latent HIV infection. By …
(CTLA4) suppress CD4+ T cell activation and may promote latent HIV infection. By …
Effects of oral cannabinoids on systemic inflammation and viral reservoir markers in people with HIV on antiretroviral therapy: results of the CTN PT028 pilot clinical …
RS Mboumba Bouassa, E Comeau, Y Alexandrova… - Cells, 2023 - mdpi.com
Chronic HIV infection is characterized by persistent inflammation despite antiretroviral
therapy (ART). Cannabinoids may help reduce systemic inflammation in people with HIV …
therapy (ART). Cannabinoids may help reduce systemic inflammation in people with HIV …
Epigenetic features of HIV-induced T-cell exhaustion persist despite early antiretroviral therapy
T cell dysfunction occurs early following HIV infection, impacting the emergence of non-AIDS
morbidities and limiting curative efforts. ART initiated during primary HIV infection (PHI) can …
morbidities and limiting curative efforts. ART initiated during primary HIV infection (PHI) can …
Higher HIV-1 Env gp120-specific antibody-dependent cellular cytotoxicity (ADCC) activity is associated with lower levels of defective HIV-1 provirus
R Yucha, ML Litchford, CS Fish, ZA Yaffe… - Viruses, 2023 - mdpi.com
A cure for HIV-1 (HIV) remains unrealized due to a reservoir of latently infected cells that
persist during antiretroviral therapy (ART), with reservoir size associated with adverse health …
persist during antiretroviral therapy (ART), with reservoir size associated with adverse health …
T cell immune discriminants of HIV reservoir size in a pediatric cohort of perinatally infected individuals
S Rinaldi, L de Armas, S Dominguez-Rodríguez… - PLoS …, 2021 - journals.plos.org
The size of the latent HIV reservoir is associated with the timing of therapeutic interventions
and overall health of the immune system. Here, we demonstrate that T cell phenotypic …
and overall health of the immune system. Here, we demonstrate that T cell phenotypic …
Adaptive NK Cells Rapidly Expand during Acute HIV Infection and Persist Despite Early Initiation of Antiretroviral Therapy
AC Hearps, J Zhou, PA Agius, P Ha, S Lee… - The Journal of …, 2024 - journals.aai.org
HIV is associated with NK cell dysfunction and expansion of adaptive-like NK cells that
persist despite antiretroviral therapy (ART). We investigated the timing of NK cell …
persist despite antiretroviral therapy (ART). We investigated the timing of NK cell …
Impact of antiretroviral therapy in primary HIV infection on natural killer cell function and the association with viral rebound and HIV DNA following treatment …
Natural Killer (NK) cells play a key role in controlling HIV replication, with potential
downstream impact on the size of the HIV reservoir and likelihood of viral rebound after …
downstream impact on the size of the HIV reservoir and likelihood of viral rebound after …