Plant-based indole alkaloids: A comprehensive overview from a pharmacological perspective

F Omar, AM Tareq, AM Alqahtani, K Dhama… - Molecules, 2021 - mdpi.com
Plant-based indole alkaloids are very rich in pharmacological activities, and the indole
nucleus is considered to contribute greatly to these activities. This review's fundamental …

β-Carboline as a privileged scaffold for multitarget strategies in Alzheimer's disease therapy

A Beato, A Gori, B Boucherle… - Journal of Medicinal …, 2021 - ACS Publications
The natural β-carboline alkaloids display similarities with neurotransmitters that can be
favorably exploited to design bioactive and bioavailable drugs for Alzheimer's disease (AD) …

Natural inhibitors of cholinesterases: chemistry, structure–activity and methods of their analysis

N Smyrska-Wieleba, T Mroczek - International Journal of Molecular …, 2023 - mdpi.com
This article aims to provide an updated description and comparison of the data currently
available in the literature (from the last 15 years) on the studied natural inhibitors of …

Potential of naturally derived alkaloids as multi-targeted therapeutic agents for neurodegenerative diseases

YR Kong, KC Tay, YX Su, CK Wong, WN Tan, KY Khaw - Molecules, 2021 - mdpi.com
Alkaloids are a class of secondary metabolites that can be derived from plants, fungi and
marine sponges. They are widely known as a continuous source of medicine for the …

Research progress of plant‐derived natural alkaloids in central nervous system diseases

Q Zhang, Q Jiang, K Sa, J Liang, D Sun… - Phytotherapy …, 2023 - Wiley Online Library
Central nervous system (CNS) disease is one of the most important causes of human death.
Because of their complex pathogenesis, more and more attention has been paid to them. At …

Traditional uses, phytochemistry and pharmacological properties of African Nauclea species: A review

R Haudecoeur, M Peuchmaur, B Pérès, M Rome… - Journal of …, 2018 - Elsevier
Abstract Ethnopharmacoalogical relevance The genus Nauclea in Africa comprises seven
species. Among them, N. latifolia, N. diderrichii and N. pobeguinii are widely used by the …

Total syntheses of (−)‐strictosidine and related indole alkaloid glycosides

J Sakamoto, Y Umeda, K Rakumitsu… - Angewandte Chemie …, 2020 - Wiley Online Library
A collective synthesis of glycosylated monoterpenoid indole alkaloids is reported. A highly
diastereoselective Pictet–Spengler reaction with α‐cyanotryptamine and secologanin …

Nauclea latifolia: biological activity and alkaloid phytochemistry of a West African tree

B Boucherle, R Haudecoeur, EF Queiroz… - Natural product …, 2016 - pubs.rsc.org
Covering up to 2016 Nauclea latifolia (syn. Sarcocephalus latifolius, Rubiaceae), commonly
called the African pincushion tree, is a plant widely used in folk medicine in different regions …

Cholinesterase inhibitory activity of isoquinoline alkaloids from three Cryptocarya species (Lauraceae)

WNNW Othman, SY Liew, KY Khaw… - Bioorganic & medicinal …, 2016 - Elsevier
Alzheimer's disease is the most common form of dementia among older adults.
Acetylcholinesterase and butyrylcholinesterase are two enzymes involved in the breaking …

Biological activities of snowdrop (Galanthus spp., Family Amaryllidaceae)

CK Kong, LE Low, WS Siew, WH Yap… - Frontiers in …, 2021 - frontiersin.org
Snowdrop is an iconic early spring flowering plant of the genus Galanthus (Amaryllidaceae).
Galanthus species (Galanthus spp.) are economically important plants as ornaments …