Inhibitors of connexin and pannexin channels as potential therapeutics
J Willebrords, M Maes, SC Yanguas… - Pharmacology & …, 2017 - Elsevier
While gap junctions support the exchange of a number of molecules between neighboring
cells, connexin hemichannels provide communication between the cytosol and the …
cells, connexin hemichannels provide communication between the cytosol and the …
General anaesthetic actions on ligand-gated ion channels
MD Krasowski, NL Harrison - Cellular and Molecular Life Sciences CMLS, 1999 - Springer
The molecular mechanisms of general anaesthetics have remained largely obscure since
their introduction into clinical practice just over 150 years ago. This review describes the …
their introduction into clinical practice just over 150 years ago. This review describes the …
Contrasting synaptic actions of the inhalational general anesthetics isoflurane and xenon.
SL De Sousa, R Dickinson, WR Lieb, NP Franks - Anesthesiology, 2000 - europepmc.org
Background The mechanisms by which the inhalational general anesthetics isoflurane and
xenon exert their effects are unknown. Moreover, there have been surprisingly few …
xenon exert their effects are unknown. Moreover, there have been surprisingly few …
The howling cortex: seizures and general anesthetic drugs
IMPLICATIONS: While anesthetic-induced generalized tonic-clonic convulsions are rare,
electroencephalographic seizure-like activity is common and may not be entirely benign …
electroencephalographic seizure-like activity is common and may not be entirely benign …
How to close a gap junction channel: Efficacies and potencies of uncoupling agents
R Rozental, M Srinivas, DC Spray - Connexin methods and protocols, 2001 - Springer
There are several reasons that one might want to selectively do away with gap junction
channels. Of critical importance to electrophysiologists, coupling interferes with …
channels. Of critical importance to electrophysiologists, coupling interferes with …
Modeling the effects of anesthesia on the electroencephalogram
Changes to the electroencephalogram (EEG) observed during general anesthesia are
modeled with a physiological mean field theory of electrocortical activity. To this end a …
modeled with a physiological mean field theory of electrocortical activity. To this end a …
Neocortex is the major target of sedative concentrations of volatile anaesthetics: strong depression of firing rates and increase of GABAA receptor‐mediated inhibition
H Hentschke, C Schwarz… - European Journal of …, 2005 - Wiley Online Library
General anaesthetics cause sedation, amnesia and hypnosis. Although these clinically
desired actions are indicative of an impairment of neocortical information processing, it is …
desired actions are indicative of an impairment of neocortical information processing, it is …
Different actions of general anesthetics on the firing patterns of neocortical neurons mediated by the GABA (A) receptor.
B Antkowiak - Anesthesiology, 1999 - europepmc.org
Background In cultured slice preparations of rat neocortical tissue, clinically relevant
concentrations of volatile anesthetics mainly decreased action potential firing of neurons by …
concentrations of volatile anesthetics mainly decreased action potential firing of neurons by …
Cortical inhibition during burst suppression induced with isoflurane anesthesia
JF Ferron, D Kroeger, O Chever… - Journal of …, 2009 - Soc Neuroscience
Isoflurane is a widely used anesthetic which safely and reversibly induces deep coma and
associated burst suppression (BS) electroencephalographic patterns. Here we investigate …
associated burst suppression (BS) electroencephalographic patterns. Here we investigate …
GABAA, slow: causes and consequences
M Capogna, RA Pearce - Trends in neurosciences, 2011 - cell.com
GABA A receptors in the CNS mediate both fast synaptic and tonic inhibition. Over the past
decade a phasic current with features intermediate between fast synaptic and tonic …
decade a phasic current with features intermediate between fast synaptic and tonic …