Advances in the immunology and genetics of leprosy

Z Mi, H Liu, F Zhang - Frontiers in immunology, 2020 - frontiersin.org
Leprosy, a disease caused by the intracellular parasite Mycobacterium leprae or
Mycobacterium lepromatosis, has affected humans for more than 4,000 years and is a …

New insights at the interface between leprosy and immune-mediated rheumatic diseases

VA Cruz, CP Albuquerque, MFBR Guimarães… - Frontiers in …, 2023 - frontiersin.org
Leprosy is an infectious and contagious disease of slow evolution, triggered by
Mycobacterium leprae. Arthritis is its third most common manifestation, after cutaneous and …

Blood RNA signature RISK4LEP predicts leprosy years before clinical onset

M Tió-Coma, SM Kiełbasa, SJF van den Eeden… - …, 2021 - thelancet.com
Background Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is often
late-or misdiagnosed leading to irreversible disabilities. Blood transcriptomic biomarkers …

Association between SNPs in microRNAs and microRNAs-machinery genes with susceptibility of leprosy in the amazon population

MNS da Silva, DF da Veiga Borges Leal… - International Journal of …, 2022 - mdpi.com
Leprosy is a chronic neurodermatological disease caused by the bacillus Mycobacterium
leprae. Recent studies show that SNPs in genes related to miRNAs have been associated …

[HTML][HTML] Neuropathic corneal pain: Tear proteomic and neuromediator profiles, imaging features, and clinical manifestations

C Liu, MTY Lin, IXY Lee, JHF Wong, D Lu… - American journal of …, 2024 - Elsevier
PURPOSE To investigate the tear proteomic and neuromediator profiles, in vivo confocal
microscopy (IVCM) imaging features, and clinical manifestations in neuropathic corneal pain …

Schwann cells as underestimated, major players in human skin physiology and pathology

ER Bray, J Chéret, G Yosipovitch… - Experimental …, 2020 - Wiley Online Library
Schwann cells (SCs) have long been recognized for their ability to support repair and
promote axon regeneration following injury to the peripheral nervous system. In response to …

Mitochondria in Mycobacterium Infection: From the Immune System to Mitochondrial Haplogroups

FG Souza, GC Cavalcante - International Journal of Molecular Sciences, 2022 - mdpi.com
In humans, mitochondria play key roles in the regulation of cellular functions, such as the
regulation of the innate immune response and are targets of several pathogenic viruses and …

Modulation of the Response to Mycobacterium leprae and Pathogenesis of Leprosy

N Cabral, V de Figueiredo, M Gandini… - Frontiers in …, 2022 - frontiersin.org
The initial infection by the obligate intracellular bacillus Mycobacterium leprae evolves to
leprosy in a small subset of the infected individuals. Transmission is believed to occur …

Whole mitogenome sequencing uncovers a relation between mitochondrial heteroplasmy and leprosy severity

FG de Souza, MB da Silva, GS de Araújo, CS Silva… - Human Genomics, 2023 - Springer
Background In recent years, the mitochondria/immune system interaction has been
proposed, so that variants of mitochondrial genome and levels of heteroplasmy might …

Transcriptome immune-regulatory differences between leprosy patients and type 1 reaction patients, before onset of symptoms

W Correa-Macedo, M Dallmann-Sauer… - PLOS Neglected …, 2024 - journals.plos.org
Leprosy is a chronic disease of the skin and peripheral nerves caused by Mycobacterium
leprae. A major public health and clinical problem are leprosy reactions, which are …