Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

The exosome complex of 3′→ 5′ exonucleases is an important component of the RNA-
processing machinery in eukaryotes. This complex functions in the accurate processing of …

The exosome regulates the processing, degradation, and surveillance of a plethora of RNA
species. However, little is known about how the exosome recognizes and is recruited to its …

Hsp90 is a ubiquitous and essential molecular chaperone that plays central roles in many
signaling and other cellular pathways. The in vivo and in vitro activity of Hsp90 depends on …

The two closely related AAA+ family ATPases Rvb1 and Rvb2 are part of several critical
multiprotein complexes, and, thus, are involved in a wide range of cellular processes …

Hsp90 is a highly conserved molecular chaperone that is involved in modulating a multitude
of cellular processes. In this study, we identify a function for the chaperone in RNA …

During the assembly process of ribosomal subunits, their structural components, the
ribosomal RNAs (rRNAs) and the ribosomal proteins (r-proteins) have to join together in a …

Small ribosomal subunits are co-transcriptionally assembled on the nascent precursor rRNA
in Saccharomyces cerevisiae. It is unknown how the highly intertwined structure of 60S large …

The nuclear exosome and the associated RNA helicase Mtr4 participate in the processing of
several ribonucleoprotein particles (RNP), including the maturation of the large ribosomal …

Hsp90 (heat shock protein 90) is an ATP-dependent molecular chaperone regulated by
collaborating proteins called cochaperones. This machinery is involved in the …