In different areas of the heart, action potential waveforms differ due to differences in the
expressions of sodium, calcium, and potassium channels. One of the characteristics of …

Existing therapies to improve heart function target β-adrenergic receptor (β-AR) signaling
and Ca 2+ handling and often lead to adverse outcomes. This underscores an unmet need …

Sinoatrial node cardiomyocytes (SANcm) possess automatic, rhythmic electrical activity.
SAN rate is influenced by autonomic nervous system input, including sympathetic nerve …

The striking increase of uterine blood flow during pregnancy is essential for normal fetal
development as well as for cardiovascular well‐being of the mother. Yet, the underlying …

Cardiomyocytes (CMs) lost during ischemic cardiac injury cannot be replaced due to their
limited proliferative capacity. Calcium is an important signal transducer that regulates key …

Calcium influx through voltage-gated calcium channels, Cav1. 2, in cardiomyocytes initiates
excitation-contraction coupling in the heart. The force and rate of cardiac contraction are …

Cardiomyocytes (CMs) lost during ischemic cardiac injury cannot be replaced due to their
limited proliferative capacity. Calcium is an important signal transducer that regulates key …

Heart failure is a major public health problem and a leading cause of mortality. This clinical
condition affects populations of all ages, and is the result of various cardiomyopathies …