Arynes are among the most active organic intermediates and have found numerous
applications in expeditious preparation of substituted arenes. In the past 20 years, chemists …

The total syntheses of polycyclic natural products by exploiting an aryne as the key reactive
species are reviewed. A short introduction summarizes the basic reactivities of aryne …

Covering: 2011 to 2022 The natural world is a prolific source of some of the most interesting,
rare, and complex molecules known, harnessing sophisticated biosynthetic machinery …

Concise syntheses of the Cephalotaxus norditerpenoids cephanolides A–D (8–14 steps
from commercial material) using a common late-stage synthetic intermediate are described …

Arynes, strained cyclic alkynes, and strained cyclic allenes were validated as plausible
intermediates in the 1950s and 1960s. Despite initially being considered mere scientific …

Inflammatory bowel diseases (IBD) are the incurable chronic recurrent gastrointestinal
disorders and currently lack in safe and effective drugs. In this study, patchouli alcohol, a …

The first asymmetric total synthesis of the hexacyclic veatchine-type C20-diterpenoid
alkaloid (−)-garryine is presented. Key steps include a Pd-catalyzed enantioselective Heck …

The diterpenoid alkaloids are a family of extremely important natural products that have long
been a research hotspot due to their myriad of intricate structures and diverse biological …

The first total synthesis of an arcutine-type C20-diterpenoid alkaloid arcutinine has been
achieved in both racemic and asymmetric forms. Construction of the C4 quaternary center …

We have accomplished the asymmetric total synthesis of arcutinidine, arcutinine, and
arcutine, three arcutine-type C20-diterpenoid alkaloids. A pentacyclic intermediate was …