Typical bioprocess comprises of different unit operations wherein a near optimal
environment is required for cells to grow, divide, and synthesize the desired product …

Real‐time monitoring of bioprocesses by the integration of analytics at critical unit
operations is one of the paramount necessities for quality by design manufacturing and real …

The biopharmaceutical industry continuously seeks to optimize the critical quality attributes
to maintain the reliability and cost‐effectiveness of its products. Such optimization demands …

Mammalian cells produce up to 80% of the commercially available therapeutic proteins, with
Chinese Hamster Ovary (CHO) cells being the primary production host. Manufacturing …

The ambr250 high-throughput bioreactor platform was adopted to provide a highly-
controlled environment for a project investigating genome instability in Chinese hamster …

Analytical testing of product quality attributes and process parameters during the biologics
development (Process analytics) has been challenging due to the rapid growth of …

Every year, millions of people are infected by the influenza virus around the world, which
results in more than half a million deaths, particularly among the more vulnerable …

Process control strategies based on the physiological status of cells have recently been
used to enhance mammalian cell culture productivity and robustness. In this study, we …

Fed-batch culture is widely used in biopharmaceutical production owing to its superior
productivity; however, optimizing feeding trajectories remains a challenge. In this study, we …

Vesicular stomatitis virus (VSV) has been increasingly demonstrated as a promising viral
vector platform. As the interest over this modality for vaccine and gene therapy applications …