Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …

Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver disorders. It is defined by the
presence of steatosis in more than 5% of hepatocytes with little or no alcohol consumption …

The accumulation of deficits with increasing age results in a decline in the functional
capacity of multiple organs and systems. These changes can have a significant influence on …

The deleterious effects of PCB 126 are complex, and the role of the liver in modifying toxic
insult is not well understood. We utilized metabolomics approaches to compare liver …

Background & Aims N‐linked glycosylation of proteins is critical for proper protein folding
and trafficking to the plasma membrane. Drug transporters are one class of proteins that …

The kidneys are a pair of important organs that excretes endogenous waste and exogenous
biological agents from the body. Numerous transporters are involved in the excretion …

Multidrug and toxin extrusion (MATE; SLC47A) proteins are membrane transporters
mediating the excretion of organic cations and zwitterions into bile and urine and thereby …

Background. Honokiol (HNK) has been reported to possess various beneficial effects in the
context of metabolic disorders, including fatty liver, insulin resistance, and oxidative stress …

Purpose The glucagon-like peptide-1 receptor (GLP-1R) is an effective therapeutic target for
type 2 diabetes mellitus (T2DM) and non-alcoholic steatohepatitis (NASH). Research has …

In the past few decades, great conceptual and technological advances have been made in
the field of toxicology, but animal model–based research still remains one of the most widely …