ESX secretion systems: mycobacterial evolution to counter host immunity
MI Gröschel, F Sayes, R Simeone, L Majlessi… - Nature Reviews …, 2016 - nature.com
Mycobacterium tuberculosis uses sophisticated secretion systems, named 6 kDa early
secretory antigenic target (ESAT6) protein family secretion (ESX) systems (also known as …
secretory antigenic target (ESAT6) protein family secretion (ESX) systems (also known as …
Virulence factors of the Mycobacterium tuberculosis complex
MA Forrellad, LI Klepp, A Gioffré, J Sabio y Garcia… - Virulence, 2013 - Taylor & Francis
The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …
[HTML][HTML] Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death
R Simeone, A Bobard, J Lippmann, W Bitter… - PLoS …, 2012 - journals.plos.org
Survival within macrophages is a central feature of Mycobacterium tuberculosis
pathogenesis. Despite significant advances in identifying new immunological parameters …
pathogenesis. Despite significant advances in identifying new immunological parameters …
Tuberculosis pathogenesis and immunity
JA Philips, JD Ernst - Annual Review of Pathology: Mechanisms …, 2012 - annualreviews.org
Despite the development of potentially curative chemotherapy, tuberculosis (TB) continues
to cause increasing worldwide morbidity and is a leading cause of human mortality in the …
to cause increasing worldwide morbidity and is a leading cause of human mortality in the …
ESX‐1‐mediated translocation to the cytosol controls virulence of mycobacteria
D Houben, C Demangel, J Van Ingen… - Cellular …, 2012 - Wiley Online Library
Mycobacterium species, including Mycobacterium tuberculosis and Mycobacterium leprae,
are among the most potent human bacterial pathogens. The discovery of cytosolic …
are among the most potent human bacterial pathogens. The discovery of cytosolic …
Mycobacterium marinum infection in fish and man: epidemiology, pathophysiology and management; a review
Mycobacterium marinum is an opportunistic pathogen inducing infection in fresh and marine
water fish. This pathogen causes necrotizing granuloma like tuberculosis, morbidity and …
water fish. This pathogen causes necrotizing granuloma like tuberculosis, morbidity and …
Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam
To examine the transmission dynamics of Mycobacterium tuberculosis (Mtb) isolated from
tuberculosis patients in Ho Chi Minh City, Vietnam, we sequenced the whole genomes of …
tuberculosis patients in Ho Chi Minh City, Vietnam, we sequenced the whole genomes of …
Protein secretion systems in Pseudomonas aeruginosa: a wealth of pathogenic weapons
S Bleves, V Viarre, R Salacha, GPF Michel… - International Journal of …, 2010 - Elsevier
Pathogenic microorganisms have to face hostile environments while colonizing and
infecting their hosts. Unfortunately, they can cope with it and have evolved a number of …
infecting their hosts. Unfortunately, they can cope with it and have evolved a number of …
Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence
JAM Tufariello, JR Chapman… - Proceedings of the …, 2016 - National Acad Sciences
Mycobacterium tuberculosis (Mtb) encodes five type VII secretion systems (T7SS),
designated ESX-1–ESX-5, that are critical for growth and pathogenesis. The best …
designated ESX-1–ESX-5, that are critical for growth and pathogenesis. The best …
Phylogeny to function: PE/PPE protein evolution and impact on Mycobacterium tuberculosis pathogenicity
The pe/ppe genes represent one of the most intriguing aspects of the M ycobacterium
tuberculosis genome. These genes are especially abundant in pathogenic mycobacteria …
tuberculosis genome. These genes are especially abundant in pathogenic mycobacteria …