The composition and organisation of the extracellular matrix (ECM), particularly the
pericellular matrix (PCM), in articular cartilage is critical to its biomechanical functionality; the …

Tissue engineering (TE) has brought new hope for articular cartilage regeneration, as TE
can provide structural and functional substitutes for native tissues. The basic elements of TE …

Introduction: Chondrocytes perceive and respond to mechanical loading as signals that
regulate their metabolism. Joint loading exposes chondrocytes to multiple modes of …

Mechanical stimuli regulate the chondrogenic differentiation of mesenchymal stem cells and
the homeostasis of chondrocytes, thus affecting implant success in cartilage tissue …

Hydrostatic pressure is known to regulate bovine nucleus pulposus cell metabolism, but its
mechanism in human nucleus pulposus cells (HNPCs) remains obscure, which attracts our …

Osteoarthritis (OA) is the most common joint disease in older adults and is characterized by
a gradual degradation of articular cartilage due to decreased cartilage matrix gene …

Introduction Chondrocytes are continuously exposed to loads placed upon them.
Physiological loads are pivotal to the maintenance of articular cartilage health, while …

Cell volume and shape changes play a pivotal role in cellular mechanotransduction,
governing cellular responses to external loading. Understanding the dynamics of cell …

The fungal cell wall is the initial barrier for the fungi against diverse external stresses, such
as osmolarity changes, harmful drugs, and mechanical injuries. This study explores the roles …

Treatment of osteoarthritic patients requires the development of morphologically and
mechanically complex hyaline cartilage at the injury site. A tissue engineering approach …