Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug
administration routes. Oral and injectable drug administration are the most common routes …

Cell-based therapy is emerging as a promising strategy for treating a wide range of human
diseases, such as diabetes, blood disorders, acute liver failure, spinal cord injury, and …

Hyaluronic acid (HA) is a glycosaminoglycan that is found in extracellular tissue in many
parts of the body. It is a material of increasing importance to biomaterials science and is …

Abstract 3D printing is an additive manufacturing technique capable of producing various 3D
drug products, medical devices, tissues and organs from digital designs. The first FDA …

Islet transplantation to restore endogenous insulin secretion is a promising therapy for type 1
diabetes in clinic. However, host immune rejection seriously limits the survival of …

The microvasculature in the pancreatic islet is highly specialized for glucose sensing and
insulin secretion. Although pancreatic islet transplantation is a potentially life-changing …

Cutinases are α/β hydrolases, and their role in nature is the degradation of cutin. Such
enzymes are usually produced by phytopathogenic microorganisms in order to penetrate …

Islet transplantation is a promising long-term, compliance-free, complication-preventing
treatment for type 1 diabetes. However, islet transplantation is currently limited to a narrow …

Type 1 diabetes mellitus is an auto-immune disease causing the T-cell mediated destruction
of insulin-producing β-cells, resulting in chronic hyperglycemia. Current treatments such as …

A bioartificial endocrine pancreas is proposed as a future alternative to current treatment
options. Patients with insulin-secretion deficiency might benefit. This is the first systematic …