Lipid–an emerging platform for oral delivery of drugs with poor bioavailability

S Chakraborty, D Shukla, B Mishra, S Singh - European journal of …, 2009 - Elsevier
The sole objective of pharmaceutical science is to design successful dosage forms which
fulfill the therapeutic needs of the patients effectively. Development of new drug entities is …

Nanotechnology based approaches to enhance aqueous solubility and bioavailability of griseofulvin: a literature survey

R Kumar - Journal of Drug Delivery Science and Technology, 2019 - Elsevier
Griseofulvin (GF) is a poor aqueous soluble and high permeability drug, are classified as a
Class II drugs based on the Biopharmaceutical Classification System (BCS). Recently, GF …

[图书][B] Colloids in drug delivery

M Fanun - 2016 - taylorfrancis.com
Colloidal drug delivery systems present a range of therapeutic benefits in the treatment of a
number of challenging conditions, allowing researchers to cross barriers that have …

Prediction of food effect by bile micelles on oral drug absorption considering free fraction in intestinal fluid

K Sugano, M Kataoka, C da Costa Mathews… - European journal of …, 2010 - Elsevier
The purpose of the present study was to derive a theoretical framework for prediction of the
food effects by interactions with bile micelles on oral drug absorption. The effect of bile …

Rate-and extent-limiting factors of oral drug absorption: theory and applications

K Sugano, K Terada - Journal of Pharmaceutical Sciences, 2015 - Elsevier
The oral absorption of drugs has been represented by various concepts such as the
absorption potential, the maximum absorbable dose, the biopharmaceutics classification …

Possible reduction of effective thickness of intestinal unstirred water layer by particle drifting effect

K Sugano - International journal of pharmaceutics, 2010 - Elsevier
According to the present theory of oral absorption, in the case of solubility limited absorption,
the absorbed amount would not increase despite an increase in dose or a decrease in …

[HTML][HTML] Chemometric Methods—A Valuable Tool for Investigating the Interactions Between Antifungal Drugs (Including Antifungal Antibiotics) and Food

A Wiesner-Kiełczewska, P Zagrodzki, A Gawalska… - …, 2025 - pmc.ncbi.nlm.nih.gov
Background/Objectives: Developing antifungal drugs with lower potential for interactions
with food may help to optimize treatment and reduce the risk of antimicrobial resistance …

Fraction of a dose absorbed estimation for structurally diverse low solubility compounds

K Sugano - International journal of pharmaceutics, 2011 - Elsevier
The purpose of the present study was to investigate the prediction accuracy of the fully
mechanistic gastrointestinal unified theoretical (GUT) framework for in vivo oral absorption of …

Dimethyl silicone dry nanoemulsion inhalations: formulation study and anti-acute lung injury effect

L Zhu, M Li, J Dong, Y Jin - International journal of pharmaceutics, 2015 - Elsevier
Acute lung injury (ALI) is a severe disease, leading to death if not treated quickly. An
emergency medicine is necessary for ALI therapy. Dimethyl silicone (DMS) is an effective …

Influence of food on paediatric gastrointestinal drug absorption following oral administration: a review

HK Batchelor - Children, 2015 - mdpi.com
The objective of this paper was to review existing information regarding food effects on drug
absorption within paediatric populations. Mechanisms that underpin food–drug interactions …