Maximum life span differences among animal species exceed life span variation achieved
by experimental manipulation by orders of magnitude. The differences in the characteristic …

Nonenzymatic molecular modifications induced by reactive carbonyl species (RCS)
generated by peroxidation of membrane phospholipids acyl chains play a causal role in the …

Oxidative stress plays an important role in the pathogenesis of Parkinson's disease (PD). In
a population‐based, case‐control study we examined whether dietary intake of antioxidants …

The membrane pacemaker theory of aging is an extension of the oxidative stress theory of
aging. It emphasises variation in the fatty acid composition of membranes as an important …

We used a potent inhibitor of glucosylceramide synthase to test whether substrate
deprivation could lower globotriaosylceramide levels in α-galactosidase A (α-gal A) …

The beta-amyloid hypothesis of Alzheimer's Disease (AD) has dominated the thinking and
research in this area for over a decade and a half. While there has been a great deal of effort …

Sphingomyelin (SM) is a prominent phospholipid component of cell membranes that has
evolved diverse functions in cells beyond its role in membrane structural organization …

—Two different aspects of learning (spatial and nonspatial) and two different types of
memory (reference and working) were simultaneously measured in populations of 3 …

Mitochondria are arbiters in the fragile balance between cell life and death. These
organelles present an intricate membrane system, with a peculiar lipid composition and …

Glial fibrillary acidic protein (GFAP), an intermediate filament of astrocytes, shows increased
expression during aging. Because we found that chronic food restriction retards the increase …