The DNA topoisomerase enzymes are essential to cell function and are found ubiquitously
in all domains of life. The various topoisomerase enzymes perform a wide range of functions …

Topoisomerase II is an essential enzyme that plays critical roles in many DNA processes,
including chromosome segregation. In order to carry out its important physiological …

Regulation of the transcription machinery is one of the many ways to achieve control of gene
expression. This has been done either at the transcription initiation stage or at the …

In contrast to the deregulated hepatocellular division that is a feature of many hepatic
diseases and malignancies, physiologic liver growth during embryonic development and …

To perform double-stranded DNA passage, type II topoisomerases generate a covalent
enzyme-cleaved DNA complex (ie cleavage complex). Although this complex is a requisite …

Astable cell line (GT2-LPk) derived from LLC-Pk was created in which endogenous DNA
topoisomerase IIα (topoIIα) protein was downregulated and replaced by the expression of …

The human papillomavirus (HPV) transcription/replication factor E2 is essential for the life
cycle of HPVs. E2 protein binds to DNA target sequences in the viral long control regions to …

Zearalenone (ZEA), a pathogenic toxin produced by Fusarium, is widely detected in moldy
feed materials. Previous studies have reported that ZEA exerts a harmful influence on …

The mechanism by which type-2A topoisomerases transport one DNA duplex through a
transient double-strand break produced in another exhibits fascinating traits. One of them is …

Introduction c-erbB2 (also known as HER-2/neu) and topoisomerase IIα are frequently
overexpressed in breast cancer. The aim of the study was to analyze retrospectively whether …