The coronavirus disease 2019 (COVID-19) pandemic has elicited a swift response by the
scientific community to elucidate the pathogenesis of severe acute respiratory syndrome …

The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19
pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring …

Background Estimates of influenza-associated mortality are important for national and
international decision making on public health priorities. Previous estimates of 250 000–500 …

Background Although the burden of influenza is often discussed in the context of historical
pandemics and the threat of future pandemics, every year a substantial burden of lower …

Background Estimates of influenza disease burden are broadly useful for public health,
helping national and local authorities monitor epidemiologic trends, plan and allocate …

Systems biological analysis of immunity to the trivalent inactivated influenza vaccine (TIV) in
humans revealed a correlation between early expression of TLR5 and the magnitude of the …

Annual estimates of the influenza disease burden provide information to evaluate programs
and allocate resources. We used a multiplier method with routine population-based …

Abstract Problem/Condition: Overall, the prevalence of illness attributable to vaccine-
preventable diseases is greater among adults than among children. Adults are …

The Vaccines for Children (VFC) program was created by the Omnibus Budget
Reconciliation Act of 1993 (1) and first implemented in 1994. VFC was designed to ensure …