Various next generation sequencing (NGS) based strategies have been successfully used in
the recent past for tracing origins and understanding the evolution of infectious agents …

Influenza and other respiratory viral infections are the most common type of acute respiratory
infection. Viral infections predispose patients to secondary bacterial infections, which often …

Despite limited genomic diversity, severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has shown a wide range of clinical manifestations in different patient populations …

Metagenomic next-generation sequencing (mNGS) for pan-pathogen detection has been
successfully tested in proof-of-concept case studies in patients with acute illness of unknown …

Context.—Metagenomic sequencing can be used for detection of any pathogens using
unbiased, shotgun next-generation sequencing (NGS), without the need for sequence …

We report unbiased metagenomic detection of chikungunya virus (CHIKV), Ebola virus
(EBOV), and hepatitis C virus (HCV) from four human blood samples by MinION nanopore …

A 14-year-old boy with severe combined immunodeficiency presented three times to a
medical facility over a period of 4 months with fever and headache that progressed to …

Noroviruses are the most frequent cause of epidemic acute gastroenteritis in the United
States. Between September 2013 and August 2016, 2,715 genotyped norovirus outbreaks …

Transcriptomics studies often rely on partial reference transcriptomes that fail to capture the
full catalogue of transcripts and their variations. Recent advances in sequencing …

Background Bloodstream infections remain one of the major challenges in intensive care
units, leading to sepsis or even septic shock in many cases. Due to the lack of timely …