GABA neurons and GABA receptors are conspicuous elements of cerebral cortical
organization. They serve to shape the stimulus-response properties of neurons in the …

After manipulations of the periphery that reduce or enhance input to the somatosensory
cortex, affected parts of the body representation will contract or expand, often over many …

Background: Up-regulation of γ-aminobutyric acid A (GABA A) receptors and decreased
GABA uptake in the cerebral cortex of schizophrenics suggest altered GABAergic …

Maintaining the proper balance between excitation and inhibition is necessary to prevent
cortical circuits from either falling silent or generating epileptiform activity. One mechanism …

1. Field potential recordings were used in rat motor cortex (MI) slice preparations to
investigate the potential for activity-dependent modifications in the effectiveness of synaptic …

The excitability of cortical circuits is modulated by interneurons that release the inhibitory
neurotransmitter GABA. In primate and rodent visual cortex, activity deprivation leads to a …

Nuclear protein transport is integral to eukaryotic cell processes such as differentiation,
transformation, and the control of gene expression. Although the targeting role of nuclear …

Two genes encode two forms of glutamate decarboxylase, GAD65 and GAD67. Because the
two GADs differ in subcellular distribution and interactions with the cofactor pyridoxal …

Intracellular targeting may enable protein kinases with broad substrate-specificities, such as
multifunctional Ca2+/calmodulin-dependent protein kinase (CaM kinase) to achieve a …

Calcium/calmodulin-dependent protein kinase II (CaMKII) has diverse roles in virtually all
cell types and it is regulated by a plethora of mechanisms. Local changes in Ca2+ …