The Hemostatic System as a Modulator of Atherosclerosis | New England Journal of Medicine
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Diabetic retinopathy is the leading cause of blindness in working age adults, and is
projected to be a significant future health concern due to the rising incidence of diabetes …

Background Group 1 pulmonary arterial hypertension (PAH) is a rare disease with high
mortality despite recent therapeutic advances. Pathogenic remodeling of pulmonary …

Purpose Pulmonary arterial hypertension (PAH) is a rare, progressive vasculopathy with
significant cardiopulmonary morbidity and mortality. Genetic testing is currently …

Despite the widespread use of conventional and contemporary methods to detect ovarian
cancer development, ovarian cancer remains a common and commonly fatal gynecological …

Background—The increasing incidence of diabetes mellitus will result in a new epidemic of
heart failure unless novel treatments able to halt diabetic cardiomyopathy early in its course …

The kinin–kallikrein system (KKS) is an endogenous multiprotein cascade, the activation of
which leads to triggering of the intrinsic coagulation pathway and enzymatic hydrolysis of …

The kallikrein-related peptidases (KLKs) represent the largest family of serine proteases
within the human genome and are expressed in various tissues. Although they regulate …

Rationale: Phosphoinositide 3-kinase (PI3K) γ is expressed in hematopoietic cells,
endothelial cells (ECs), and cardiomyocytes and regulates different cellular functions …

Human kallikrein‐related peptidases (KLKs) are a subgroup of serine proteases that
participate in proteolytic pathways and control protein levels in normal physiology as well as …