Messenger RNA (mRNA) is an emerging class of therapeutic agent for the prevention and
treatment of a wide range of diseases. The recent success of the two highly efficacious …

RNA-based therapy is a promising and potential strategy for disease treatment by
introducing exogenous nucleic acids such as messenger RNA (mRNA), small interfering …

Recent years have witnessed incredible growth in RNA therapeutics, which has benefited
significantly from decades of research on lipid nanoparticles, specifically its key component …

Immunotherapy with immune checkpoint blockade (ICB) has shown limited benefits in
hepatocellular carcinoma (HCC) and other cancers, mediated in part by the …

With the emerging advances in utilizing nanocarriers for biomedical applications, a
molecular-level understanding of the in vivo fate of nanocarriers is necessary. After …

Background Poly (lactic acid)(PLA) and poly (lactic-co-glycolic acid)(PLGA) are among the
well-documented FDA-approved polymers used for the preparation of safe and effective …

The intrinsic limits of conventional cancer therapies prompted the development and
application of various nanotechnologies for more effective and safer cancer treatment …

Advances in nanoparticle synthesis and engineering have produced nanoscale agents
affording both therapeutic and diagnostic functions that are often referred to by the …

Antisense oligonucleotides (ASOs) bind sequence specifically to the target RNA and
modulate protein expression through several different mechanisms. The ASO field is an …

Synthetic mRNA represents an exciting cancer vaccine technology for the implementation of
effective cancer immunotherapy. However, inefficient in vivo mRNA delivery along with a …