Exploiting LRRC15 as a novel therapeutic target in cancer

U Ray, CL Pathoulas, P Thirusangu, JW Purcell… - Cancer research, 2022 - AACR
Abundant fibrotic stroma is a typical feature of most solid tumors, and stromal activation
promotes oncogenesis, therapy resistance, and metastatic dissemination of cancer cells …

The elusive coreceptors for the SARS-CoV-2 spike protein

RL Berkowitz, DA Ostrov - Viruses, 2022 - mdpi.com
Evidence suggests that the N-terminal domain (NTD) of the SARS-CoV-2 spike protein
interacts with host coreceptors that participate in viral entry. Resolving the identity of …

Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs

L Loo, MA Waller, CL Moreno, AJ Cole, AO Stella… - PLoS …, 2023 - journals.plos.org
Although ACE2 is the primary receptor for Severe Acute Respiratory Syndrome Coronavirus
2 (SARS-CoV-2) infection, a systematic assessment of host factors that regulate binding to …

Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence

JS Gisby, NB Buang, A Papadaki, CL Clarke… - Nature …, 2022 - nature.com
Patients with end-stage kidney disease (ESKD) are at high risk of severe COVID-19. Here,
we perform longitudinal blood sampling of ESKD haemodialysis patients with COVID-19 …

LRRC15 inhibits SARS-CoV-2 cellular entry in trans

J Song, RD Chow, MA Peña-Hernández, L Zhang… - Plos …, 2022 - journals.plos.org
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is mediated by
the entry receptor angiotensin-converting enzyme 2 (ACE2). Although attachment factors …

LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein

J Shilts, TWM Crozier, A Teixeira-Silva, I Gabaev… - PLoS …, 2023 - journals.plos.org
The interactions between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-
2) and human host factors enable the virus to propagate infections that lead to Coronavirus …

Dissecting the Molecular Basis of Host Leucine-Rich Repeat Containing 15 Mediated Interaction with Receptor Binding Domain of SARS-CoV-2 Spike Protein: A …

S Mishra, M Sharma, MK Singh, S Pati… - The Journal of Physical …, 2023 - ACS Publications
The detection of leucine-rich repeat containing 15 (LRRC15) as a connecting link with
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the possibility …

[HTML][HTML] LRRC15 is an inhibitory receptor blocking SARS-CoV-2 spike-mediated entry in trans

J Song, RD Chow, M Pena-Hernandez, L Zhang… - bioRxiv, 2021 - ncbi.nlm.nih.gov
SARS-CoV-2 infection is mediated by the entry receptor ACE2. Although attachment factors
and co-receptors facilitating entry are extensively studied, cellular entry factors inhibiting …

Technologies to decode the multicellular networks within the human body

J Shilts - 2022 - repository.cam.ac.uk
This is a story about how it is possible for collections of cells to physically assemble into
coordinated multicellular systems. In other words, how millions of individual cells are able to …

Molecular Tissue Responses to Mechanical Loading

JPRO Orgel - International Journal of Molecular Sciences, 2022 - mdpi.com
The intention of this special edition is to highlight the benefits of a holistic approach to
computational and experimental approaches in the context of aiding the diagnosis and …