MicroRNAs (miRNAs) are important regulators of gene expression and like any other gene,
their coding sequences are subject to genetic variation. Variants in miRNA genes can have …

The last decade has seen tremendous improvements in the understanding of human
variations and their association with human traits and diseases. The availability of high …

Motivation: The caspase family of cysteine proteases play essential roles in key biological
processes such as programmed cell death, differentiation, proliferation, necrosis and …

RNA-cleaving ribozymes are promising candidates as general tools of RNA interference
(RNAi) in gene manipulation. However, compared with other RNA systems, such as siRNA …

Acute gene inactivation using short hairpin RNA (shRNA, knockdown) in developing brain is
a powerful technique to study genetic function; however, discrepancies between knockdown …

Patients with lung adenocarcinoma may benefit from recently developed molecular targeted
therapies. However, analogous advanced treatments are not available for patients with lung …

We report an advanced web server, the plant-specific small noncoding RNA interference
tool pssRNAit, which can be used to design a pool of small interfering RNAs (siRNAs) for …

The ribonuclease III enzyme Drosha has a central role in the biogenesis of microRNA
(miRNA) by binding and cleaving hairpin structures in primary RNA transcripts into precursor …

Background Small molecular cofactors or ligands play a crucial role in the proper functioning
of cells. Accurate annotation of their target proteins and binding sites is required for the …

The BLM helicase protein plays a vital role in DNA replication and the maintenance of
genomic integrity. Variation in the BLM helicase gene resulted in defects in the DNA repair …