Natural tripeptide-based inhibitor of multifaceted amyloid β toxicity
K Rajasekhar, C Madhu… - ACS chemical …, 2016 - ACS Publications
Accumulation of amyloid beta (Aβ) peptide and its aggregates in the human brain is
considered as one of the hallmarks of Alzheimer's disease (AD). The polymorphic oligomers …
considered as one of the hallmarks of Alzheimer's disease (AD). The polymorphic oligomers …
Vanillin benzothiazole derivative reduces cellular reactive oxygen species and detects amyloid fibrillar aggregates in Alzheimer's disease brain
The misfolding of amyloid beta (Aβ) peptides into Aβ fibrillary aggregates is a major hallmark
of Alzheimer's disease (AD), which responsible for the excess production of hydrogen …
of Alzheimer's disease (AD), which responsible for the excess production of hydrogen …
Engineering amyloid aggregation as a new way to eliminate cancer stem cells by the disruption of iron homeostasis
H Qin, T Cui, Z Liu, Y Zhou, J Niu, J Ren, X Qu - Nano Letters, 2021 - ACS Publications
Cancer stem cells (CSCs) play crucial roles in tumor initiation. Amyloid β (Aβ), which is
associated with Alzheimer's disease (AD), has been identified to induce cytotoxicity in tumor …
associated with Alzheimer's disease (AD), has been identified to induce cytotoxicity in tumor …
Crafting of neuroprotective octapeptide from taxol-binding pocket of β-tubulin
Microtubules play a crucial role in maintaining the shape and function of neurons. During
progression of Alzheimer's disease (AD), severe destabilization of microtubules occurs …
progression of Alzheimer's disease (AD), severe destabilization of microtubules occurs …
Amyloid β and tumorigenesis: amyloid β-induced telomere dysfunction in tumor cells
The biological functions of amyloid β (Aβ) peptides have received much attention, playing a
central role in the pathogenesis of Alzheimer's disease (AD). Recent studies have …
central role in the pathogenesis of Alzheimer's disease (AD). Recent studies have …
Enhanced anticancer effect of Combretastatin A-4 phosphate when combined with vincristine in the treatment of hepatocellular carcinoma
Tubulin targeting agents have received considerable interest as a potential tumor-selective
vascular disrupting agents, which represent another avenue for cancer growing therapeutic …
vascular disrupting agents, which represent another avenue for cancer growing therapeutic …
Genesis of neuroprotective peptoid from Aβ30–34 inhibits Aβ aggregation and AChE activity
Aβ peptide and hyper-phosphorylated microtubule associated protein (Tau) aggregation
causes severe damage to both the neuron membrane and key signal processing …
causes severe damage to both the neuron membrane and key signal processing …
Novel hexapeptide interacts with tubulin and microtubules, inhibits Aβ fibrillation, and shows significant neuroprotection
Herein, we report a novel hexapeptide, derived from activity dependent neuroprotective
protein (ADNP), that spontaneously self-assembles to form antiparallel β-sheet structure and …
protein (ADNP), that spontaneously self-assembles to form antiparallel β-sheet structure and …
Molecular docking and in vivo/in vitro studies of a novel thiadiazole Schiff base as a hepatoprotective drug against angiogenesis induced by breast cancer
NF Alqahtani, MY Alfaifi, A Shati, SEI Elbehairi… - RSC …, 2024 - pubs.rsc.org
Two new thiadiazole imidazolium salicylidene Schiff bases (TISSBs) were successfully
synthesized, and their structures were analyzed comprehensively using spectroscopic …
synthesized, and their structures were analyzed comprehensively using spectroscopic …
α-Cyclodextrin interacts close to vinblastine site of tubulin and delivers curcumin preferentially to the tubulin surface of cancer cell
Tubulin is the key cytoskeleton component, which plays a crucial role in eukaryotic cell
division. Many anticancer drugs have been developed targeting the tubulin surface …
division. Many anticancer drugs have been developed targeting the tubulin surface …