As the ancestral homeland of our species, Africa contains elevated levels of genetic diversity
and substantial population structure. Importantly, African genomes are heterogeneous: They …

Linkage disequilibrium (LD) is the correlation among nearby genetic variants. In genetic
association studies, LD is often modeled using large correlation matrices, but this approach …

Polygenic scores (PGS) can be used for risk stratification by quantifying individuals' genetic
predisposition to disease, and many potentially clinically useful applications have been …

Reaction time variability (RTV), reflecting fluctuations in response time on cognitive tasks,
has been proposed as an endophenotype for many neuropsychiatric disorders. There have …

Polygenic risk scores (PRSs) developed from multi-ancestry genome-wide association
studies (GWASs), PRS multi, hold promise for improving PRS accuracy and generalizability …

An individual's disease risk is affected by the populations that they belong to, due to shared
genetics and environmental factors. The study of fine-scale populations in clinical care is …

Major developments in the field of genetics in the past few decades have revolutionised
notions of what it means to be human. Although currently only a few populations around the …

Polygenic prediction studies in continental Africans are scarce. Africa's genetic and
environmental diversity pose a challenge that limits the generalizability of polygenic risk …

Background Genome-wide association studies (GWAS) have predominantly focused on
populations of European and Asian ancestry, limiting our understanding of genetic factors …

Polygenic risk score (PRS) predictions often show bias toward the population of available
genome-wide association studies (GWASs), which is typically of European ancestry. This …