Oxidative stress in diabetic peripheral neuropathy: Pathway and mechanism-based treatment

Q Lin, K Li, Y Chen, J Xie, C Wu, C Cui, B Deng - Molecular Neurobiology, 2023 - Springer
Diabetic peripheral neuropathy (DPN) is a major complication of diabetes mellitus with a
high incidence. Oxidative stress, which is a crucial pathophysiological pathway of DPN, has …

Mitochondrial Dysfunction and Alpha‐Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?

SM Dos Santos, CFR Romeiro… - Oxidative medicine …, 2019 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative disorder characterised by impairments in
the cognitive domains associated with orientation, recording, and memory. This pathology …

Loganin attenuates high glucose-induced schwann cells pyroptosis by inhibiting ROS generation and NLRP3 inflammasome activation

YC Cheng, LW Chu, JY Chen, SL Hsieh, YC Chang… - Cells, 2020 - mdpi.com
Diabetic peripheral neuropathy (DPN) is caused by hyperglycemia, which induces oxidative
stress and inflammatory responses that damage nerve tissue. Excessive generation of …

Metformin promotes axon regeneration after spinal cord injury through inhibiting oxidative stress and stabilizing microtubule

H Wang, Z Zheng, W Han, Y Yuan, Y Li… - Oxidative medicine …, 2020 - Wiley Online Library
Spinal cord injury (SCI) is a devastating disease that may lead to lifelong disability. Thus,
seeking for valid drugs that are beneficial to promoting axonal regrowth and elongation after …

Hyperbaric oxygen therapy counters oxidative stress/inflammation-driven symptoms in long COVID-19 patients: preliminary outcomes

S Mrakic-Sposta, A Vezzoli, G Garetto, M Paganini… - Metabolites, 2023 - mdpi.com
Long COVID-19 patients show systemic inflammation and persistent symptoms such as
fatigue and malaise, profoundly affecting their quality of life. Since improving oxygenation …

The role of oxidative stress in peripheral neuropathy

ML Mallet, M Hadjivassiliou, PG Sarrigiannis… - Journal of molecular …, 2020 - Springer
Peripheral neuropathy (PN) is a common disease affecting about 5% of the general
population after the age of 50. Causes of PN are numerous and include genetic, diabetes …

Oxidative stress response's kinetics after 60 minutes at different (30% or 100%) normobaric hyperoxia exposures

C Leveque, S Mrakic-Sposta, P Lafère… - International journal of …, 2022 - mdpi.com
Oxygen is a powerful trigger for cellular reactions and is used in many pathologies, including
oxidative stress. However, the effects of oxygen over time and at different partial pressures …

Antioxidant for neurological diseases and neurotrauma and bioengineering approaches

N Rizwana, V Agarwal, M Nune - Antioxidants, 2021 - mdpi.com
Antioxidants are a class of molecules with an innate affinity to neutralize reactive oxygen
species (ROS), which are known to cause oxidative stress. Oxidative stress has been …

Alphalipoic acid prevents oxidative stress and peripheral neuropathy in nab‐paclitaxel‐treated rats through the Nrf2 signalling pathway

H Sun, X Guo, Z Wang, P Wang… - Oxidative medicine …, 2019 - Wiley Online Library
Peripheral neuropathy is the major dose‐limiting side effect of paclitaxel (PTX), affecting
both the quality of life and the survival of cancer patients. Nab‐paclitaxel (nab‐PTX) was …

[HTML][HTML] The use of alfa-lipoic acid-R (ALA-R) in patients with mild-moderate carpal tunnel syndrome: a randomised controlled open label prospective study

M Passiatore, A Perna, R De-Vitis… - Malaysian Orthopaedic …, 2020 - ncbi.nlm.nih.gov
Results: 134 patients (74 F, 60 M) met the inclusion and exclusion criteria. In Group A, there
was a statistically significant pain reduction compared to the control Group. Using the Boston …