Activation of ATR-related protein kinase upon DNA damage recognition
M Ma, A Rodriguez, K Sugimoto - Current genetics, 2020 - Springer
Chromosomes are constantly damaged by exogenous and endogenous factors. To cope
with DNA damage, eukaryotic cells are equipped with three phosphatidylinositol 3-kinase …
with DNA damage, eukaryotic cells are equipped with three phosphatidylinositol 3-kinase …
DNA damage checkpoint execution and the rules of its disengagement
CQX Yam, HH Lim, U Surana - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Chromosomes are susceptible to damage during their duplication and segregation or when
exposed to genotoxic stresses. Left uncorrected, these lesions can result in genomic …
exposed to genotoxic stresses. Left uncorrected, these lesions can result in genomic …
Phosphoproteomics reveals distinct modes of Mec1/ATR signaling during DNA replication
Summary The Mec1/Tel1 kinases (human ATR/ATM) play numerous roles in the DNA
replication stress response. Despite the multi-functionality of these kinases, studies of their …
replication stress response. Despite the multi-functionality of these kinases, studies of their …
Sae2 controls Mre11 endo-and exonuclease activities by different mechanisms
T Tamai, G Reginato, R Ojiri, I Morita, A Avrutis… - Nature …, 2024 - nature.com
DNA double-strand breaks (DSBs) must be repaired to ensure cell survival and genomic
integrity. In yeast, the Mre11-Rad50-Xrs2 complex (MRX) collaborates with Sae2 to initiate …
integrity. In yeast, the Mre11-Rad50-Xrs2 complex (MRX) collaborates with Sae2 to initiate …
Structural basis of Mec1-Ddc2-RPA assembly and activation on single-stranded DNA at sites of damage
Summary Mec1-Ddc2 (ATR-ATRIP) is a key DNA-damage-sensing kinase that is recruited
through the single-stranded (ss) DNA-binding replication protein A (RPA) to initiate the DNA …
through the single-stranded (ss) DNA-binding replication protein A (RPA) to initiate the DNA …
Yeast ATM and ATR kinases use different mechanisms to spread histone H2A phosphorylation around a DNA double-strand break
K Li, G Bronk, J Kondev… - Proceedings of the …, 2020 - National Acad Sciences
One of the hallmarks of DNA damage is the rapid spreading of phosphorylated histone H2A
(γ-H2AX) around a DNA double-strand break (DSB). In the budding yeast Saccharomyces …
(γ-H2AX) around a DNA double-strand break (DSB). In the budding yeast Saccharomyces …
3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP
X Wang, T Ran, X Zhang, J Xin, Z Zhang, T Wu… - Science, 2017 - science.org
The ataxia telangiectasia–mutated and Rad3-related (ATR) kinase is a master regulator of
DNA damage response and replication stress in humans, but the mechanism of its activation …
DNA damage response and replication stress in humans, but the mechanism of its activation …
Mechanism of auto-inhibition and activation of Mec1ATR checkpoint kinase
In response to DNA damage or replication fork stalling, the basal activity of Mec1ATR is
stimulated in a cell-cycle-dependent manner, leading to cell-cycle arrest and the promotion …
stimulated in a cell-cycle-dependent manner, leading to cell-cycle arrest and the promotion …
Extending gene ontology with gene association networks
Motivation: Gene ontology (GO) is a widely used resource to describe the attributes for gene
products. However, automatic GO maintenance remains to be difficult because of the …
products. However, automatic GO maintenance remains to be difficult because of the …
Assembly of Slx4 signaling complexes behind DNA replication forks
Obstructions to replication fork progression, referred to collectively as DNA replication stress,
challenge genome stability. In Saccharomyces cerevisiae, cells lacking RTT 107 or SLX 4 …
challenge genome stability. In Saccharomyces cerevisiae, cells lacking RTT 107 or SLX 4 …