Objectives Tetrandrine, a natural bisbenzylisoquinoline alkaloid, possesses promising
anticancer activities on diverse tumours. This review provides systematically organized …

Chronic pain during childhood and adolescence can lead to persistent pain problems and
mental health disorders into adulthood. Posttraumatic stress disorders and depressive and …

Aims/Objectives/Background: A significant number of people who experience chronic pain
also complain of depression and sleep problems. The comorbidities and bidirectional …

Depression is a major mental disease that is ranked as the fourth leading cause of disability.
In order to avoid unwanted adverse reactions, as well as improve efficacy, current …

Thymol, a bioactive monoterpene isolated from Thymus vulgaris, has displayed inspiring
neuroprotective properties. The present study was designed to evaluate the antidepressant …

Depression is a multigenetic or multifactorial syndrome. The central neuron system (CNS)-
orientated, single target, and conventional antidepressants are insufficient and far from …

Development of new medications is a lengthy and costly process, and drug repositioning
might help to shorten the development cycle. We present a machine learning (ML) workflow …

Although icariin has been reported to have antidepressant-like effects in different animal
models, its poor oral bioavailability and low efficiency of delivery to the brain limit its …

Ethnopharmacology relevance Albiflorin, a monoterpene glycoside, is a main component of
Radix paeoniae Alba, which could be a Chinese herbal medicine used in the treatment of …

Depression is a major neuropsychiatric disease that considerably impacts individuals'
psychosocial function and life quality. Neurotrophic factors are now connected to the …