Exercise attenuates the major hallmarks of aging

N Garatachea, H Pareja-Galeano… - Rejuvenation …, 2015 - liebertpub.com
Regular exercise has multi-system anti-aging effects. Here we summarize how exercise
impacts the major hallmarks of aging. We propose that, besides searching for novel …

Regular, intense exercise training as a healthy aging lifestyle strategy: preventing DNA damage, telomere shortening and adverse DNA methylation changes over a …

M Sellami, N Bragazzi, MS Prince, J Denham… - Frontiers in …, 2021 - frontiersin.org
Exercise training is one of the few therapeutic interventions that improves health span by
delaying the onset of age-related diseases and preventing early death. The length of …

Differential effects of endurance, interval, and resistance training on telomerase activity and telomere length in a randomized, controlled study

CM Werner, A Hecksteden, A Morsch… - European heart …, 2019 - academic.oup.com
Aims It is unknown whether different training modalities exert differential cellular effects.
Telomeres and telomere-associated proteins play a major role in cellular aging with …

[HTML][HTML] Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies

M Gielen, GJ Hageman, EE Antoniou, K Nordfjall… - The American journal of …, 2018 - Elsevier
Background Even before the onset of age-related diseases, obesity might be a contributing
factor to the cumulative burden of oxidative stress and chronic inflammation throughout the …

Effect of physical activity, smoking, and sleep on telomere length: a systematic review of observational and intervention studies

R Barragán, C Ortega-Azorín, JV Sorli… - Journal of clinical …, 2021 - mdpi.com
Aging is a risk factor for several pathologies, restricting one's health span, and promoting
chronic diseases (eg, cardiovascular and neurodegenerative diseases), as well as cancer …

Identification of modulated MicroRNAs associated with breast cancer, diet, and physical activity

L Falzone, M Grimaldi, E Celentano, LSA Augustin… - Cancers, 2020 - mdpi.com
Simple Summary Healthy diet and physical activity are able to induce beneficial molecular
modifications that have been associated with a lower risk of breast cancer (BC) incidence …

Stress and immunosenescence: The role of telomerase

K de Punder, C Heim, PD Wadhwa… - Psychoneuroendocrinology, 2019 - Elsevier
Chronic stress is associated with the accelerated aging of the immune system and
represents a potent risk factor for the development and progression of a wide range of …

[HTML][HTML] Non-coding RNAs in exercise immunology: A systematic review

M Kotewitsch, M Heimer, B Schmitz… - Journal of Sport and Health …, 2024 - Elsevier
Regular physical exercise has been recognized as a potent modulator of immune function,
with its effects including enhanced immune surveillance, reduced inflammation, and …

Circulating microRNAs as potential biomarkers of exercise response

M Polakovičová, P Musil, E Laczo, D Hamar… - International journal of …, 2016 - mdpi.com
Systematic physical activity increases physical fitness and exercise capacity that lead to the
improvement of health status and athletic performance. Considerable effort is devoted to …

The shelterin protein expansion of telomere dynamics: Linking early life adversity, life history, and the hallmarks of aging

SE Wolf, I Shalev - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
Aging is characterized by functional decline occurring alongside changes to several
hallmarks of aging. One of the hallmarks includes attrition of repeated DNA sequences …