Growing evidence highlights the relevance of microbiota-gut-brain axis in the maintenance
of brain homeostasis as well as in the pathophysiology of major neurological and psychiatric …

Erythrocytes are deeply sensitive cells and important health indicators. During inflammatory
response RBC, as a part of haematological system, are exposed to circulating inflammatory …

Phosphorylation of tau at Ser 396, 404 (p-tau 396,404) is the earliest phosphorylation event
and a promising biomarker for the early diagnosis of Alzheimer's disease (AD). However, the …

The senescence-accelerated mouse prone 8 (SAMP8) mice have many pathological
features of Alzheimer's disease (AD) with aging. We previously reported that Dendrobium …

Palmitoylethanolamide (PEA), an endogenous lipid mediator, is emerging as a promising
pharmacological agent in multiple neurodegenerative disorders for its anti-inflammatory and …

Increasing evidence suggests that intestinal dysfunctions may represent early events in
Alzheimer's disease and contribute to brain pathology. This study examined the relationship …

Abstract Background Consumption of a Western-styled diet enriched in saturated fatty acids
(SFA) relative to polyunsaturated fatty acids is positively associated with risk for Alzheimer's …

Alzheimer's disease (AD) is characterized by proteasome activity impairment, oxidative
stress, and epigenetic changes, resulting in β‐amyloid (Aβ) production/degradation …

Introduction α-syn aggregates represent the pathological hallmark of synucleinopathies as
well as a frequent copathology (almost 1/3 of cases) in AD. Recent research indicates a …

The underlying mechanisms of diseases affecting the central nervous system (CNS) remain
unclear, limiting the development of effective therapeutic strategies. Remarkably, cellular …