The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer
This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …
level. First, the interactions between curcumin and its molecular targets are addressed on …
Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression
N Isakov - Seminars in cancer biology, 2018 - Elsevier
The AGC family of serine/threonine kinases (PKA, PKG, PKC) includes more than 60
members that are critical regulators of numerous cellular functions, including cell cycle and …
members that are critical regulators of numerous cellular functions, including cell cycle and …
[HTML][HTML] Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor
Protein kinase C (PKC) isozymes have remained elusive cancer targets despite the
unambiguous tumor promoting function of their potent ligands, phorbol esters, and the …
unambiguous tumor promoting function of their potent ligands, phorbol esters, and the …
Protein kinase C and other diacylglycerol effectors in cancer
EM Griner, MG Kazanietz - Nature Reviews Cancer, 2007 - nature.com
Almost three decades after the discovery of protein kinase C (PKC), we still have only a
partial understanding of how this family of serine/threonine kinases is involved in tumour …
partial understanding of how this family of serine/threonine kinases is involved in tumour …
Protein kinase C and cancer: what we know and what we do not
Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of
the most extensively studied signaling kinases. PKCs signal through multiple pathways and …
the most extensively studied signaling kinases. PKCs signal through multiple pathways and …
Tumor suppressive role for kinases phosphorylating p53 in DNA damage‐induced apoptosis
S Yogosawa, K Yoshida - Cancer science, 2018 - Wiley Online Library
Tumor suppressor p53 plays an important role in cancer prevention. Under normal
conditions, p53 is maintained at a low level. However, in response to various cellular …
conditions, p53 is maintained at a low level. However, in response to various cellular …
Targeting the protein kinase C family: are we there yet?
HJ Mackay, CJ Twelves - Nature Reviews Cancer, 2007 - nature.com
Protein kinase C (PKC) comprises a family of serine/threonine kinases that are involved in
the transduction of signals for cell proliferation, differentiation, apoptosis and angiogenesis …
the transduction of signals for cell proliferation, differentiation, apoptosis and angiogenesis …
Regulation of cell apoptosis by protein kinase c δ
C Brodie, PM Blumberg - Apoptosis, 2003 - Springer
The isoforms of the PKC family are activated in response to mitogenic stimuli, to
inflammatory stimuli, and to stress and play important roles in a variety of cellular functions …
inflammatory stimuli, and to stress and play important roles in a variety of cellular functions …
[HTML][HTML] Protein kinase C isoforms: Multi-functional regulators of cell life and death
ME Reyland - Frontiers in bioscience (Landmark edition), 2009 - ncbi.nlm.nih.gov
The protein kinase C (PKC) family consists of 10 related serine/threonine protein kinases
some of which are critical regulators of cell proliferation, survival and cell death. While early …
some of which are critical regulators of cell proliferation, survival and cell death. While early …
Protein kinase Cα (PKCα): regulation and biological function
S Nakashima - The Journal of Biochemistry, 2002 - jstage.jst.go.jp
Protein kinase Ca (PKCƒ¿) is a serine/threonine kinase and a member of the conven
tional(classical) PKCs(cPKCs), which have four conserved(C1 to C4) regions. This …
tional(classical) PKCs(cPKCs), which have four conserved(C1 to C4) regions. This …