The progression of cells from a normal differentiated state in which rates of proliferation and
apoptosis are balanced to a tumorigenic and metastatic state involves the accumulation of …

It is now widely accepted that advanced fibrosis underlies many chronic inflammatory
disorders and is the main cause of morbidity and mortality of the modern world. The …

Background and Purpose Palmitoylethanolamide (PEA) acts via several targets, including
cannabinoid CB 1 and CB2 receptors, transient receptor potential vanilloid type‐1 (TRPV1) …

The chemosensory capacity of the somatosensory system relies on the appropriate
expression of chemoreceptors, which detect chemical stimuli and transduce sensory …

Background & Aims: Robust chemical or mechanical irritation of the colon of neonatal rats
leads to chronic visceral hypersensitivity. The clinical and physiologic relevance of such …

The transient receptor potential vanilloid 1 receptor (TRPV1) is an important nociceptor
involved in neurogenic inflammation. We aimed to examine the role of TRPV1 in …

Gastrointestinal (GI) cancers are a group of diseases with very high positions in the ranking
of cancer incidence and mortality. While they show common features regarding the …

Tissue acidosis plays a pivotal role in tumor progression: in particular, interstitial acidosis
promotes tumor cell invasion, and is a major contributor to the dysregulation of tumor …

Background & Aims: The neurobiologic basis of pancreatic hyperalgesia in chronic
pancreatitis (CP) is understood poorly and there is a need to identify novel therapeutic …

(1) Background: Transient receptor potential vanilloid 3 (TRPV3) is a member of the TRP
channels family of Ca2+-permeant channels. The proteins of some TRP channels are highly …