[HTML][HTML] Antioxidants as precision weapons in war against cancer chemotherapy induced toxicity–Exploring the armoury of obscurity

K Singh, M Bhori, YA Kasu, G Bhat, T Marar - Saudi Pharmaceutical Journal, 2018 - Elsevier
Cancer is the leading cause of mortality worldwide, accounting for almost 13% of deaths in
the world. Among the conventional cancer treatments, chemotherapy is most frequently …

Biological and therapeutic activities of thymoquinone: Focus on the Nrf2 signaling pathway

M Talebi, M Talebi, T Farkhondeh… - Phytotherapy …, 2021 - Wiley Online Library
Thymoquinone is a monoterpenoid compound, which is derived from volatile and fixed oil of
Nigella sativa (Ranunculaceae). This phytochemical compound has several biological …

[HTML][HTML] Doxorubicin-induced alterations in kidney functioning, oxidative stress, DNA damage, and renal tissue morphology; Improvement by Acacia hydaspica tannin …

T Afsar, S Razak, A Almajwal, D Al-Disi - Saudi journal of biological …, 2020 - Elsevier
Doxorubicin (DOX) is an anthracycline drug used for cancer treatment. However, its
treatment is contiguous with toxic effects. We examined the nephroprotective potential of A …

Mitochondria and nuclei dual-targeted heterogeneous hydroxyapatite nanoparticles for enhancing therapeutic efficacy of doxorubicin

H Xiong, S Du, J Ni, J Zhou, J Yao - Biomaterials, 2016 - Elsevier
Dual-targeted nanoparticles have been increasingly used to realize greater anti-proliferation
effect by attacking double key sites of tumor cells. In order to retain nuclei inhibition effect …

Chemoprotective effects of curcumin on doxorubicin-induced nephrotoxicity in wistar rats: by modulating inflammatory cytokines, apoptosis, oxidative stress and …

F Benzer, FM Kandemir, S Kucukler… - … of physiology and …, 2018 - Taylor & Francis
Doxorubicin (DXR) is one of the most important chemotherapeutic agent. However,
nephrotoxicity reduces its clinical utility in humans. The aim of the study was to investigate …

Protective effects of dioscin against doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammation

Y Zhang, Y Xu, Y Qi, L Xu, S Song, L Yin, X Tao… - Toxicology, 2017 - Elsevier
Dioscin shows active effects against renal ischemia/reperfusion injury and
lipopolysaccharide-induced inflammatory kidney injury, however, little is known concerning …

[HTML][HTML] Anti-inflammatory, anti-apoptotic, and antioxidant roles of honey, royal jelly, and propolis in suppressing nephrotoxicity induced by doxorubicin in male albino …

HK Mohamed, MA Mobasher, RA Ebiya, MT Hassen… - Antioxidants, 2022 - mdpi.com
Nephrotoxicity is one of the limiting factors for using doxorubicin (DOX). Honey, propolis,
and royal jelly were evaluated for their ability to protect against nephrotoxicity caused by …

[HTML][HTML] Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney

A Abdeen, A Abdelkader, D Elgazzar… - Biomedicine & …, 2020 - Elsevier
Piroxicam (PM) is an oxicam-NSAID commonly recommended for various pain and
associated inflammatory disorders. However, it is reported to have a gastric and hepato …

The effects of mesenchymal stem cell mitochondrial transplantation on doxorubicin‐mediated nephrotoxicity in rats

GB Kubat, M Ozler, O Ulger, O Ekinci… - … of biochemical and …, 2021 - Wiley Online Library
The effect of dysfunctional mitochondria in several cell pathologies has been reported in
renal diseases, including diabetic nephropathy and acute kidney injury. Previous studies …

[HTML][HTML] Ceratonia siliqua pods (Carob) methanol extract alleviates doxorubicin-induced nephrotoxicity via antioxidant, anti-inflammatory and anti-apoptotic …

AH Atta, SA Atta, MS Khattab, THA El-Aziz… - … Science and Pollution …, 2023 - Springer
Doxorubicin (DOX) is an anti-neoplastic therapy, but its use is limited by its deleterious toxic
effects including nephrotoxicity and cardiotoxicity. This work aimed at assessing the …