Research on the neurobiology of the kynurenine pathway has suffered years of relative
obscurity because tryptophan degradation, and its involvement in both physiology and major …

As a major metabolite of kynurenine in the oxidative metabolism of tryptophan, kynurenic
acid is of considerable biological and clinical importance as an endogenous antagonist of …

Covering: 1996–December 2016 The human Ether-à-go-go Related Gene (hERG) channel
is a voltage-gated potassium channel playing an essential role in the normal electrical …

Background: Acetylcholinesterase inhibitors (AChEis) including donepezil, galantamine and
rivastigmine are used to treat Alzheimer's disease (AD). This study aimed to evaluate …

Donepezil, galantamine, and rivastigmine are the three acetylcholinesterase inhibitors
(AChEIs), out of a total of only four medications prescribed in the treatment of Alzheimer's …

Several studies suggest QT prolongation and torsade de pointes with acetylcholine-esterase
inhibitors. We therefore examined the electrophysiologic profile of donepezil, rivastigmine …

Donepezil is a potent, selective inhibitor of acetylcholinesterase, which is used for the
treatment of Alzheimer's disease. Whole-cell patch-clamp technique and Western blot …

Objective: Cholinesterase inhibitor (ChEIs) is the first-line drug for Alzheimer's disease (AD).
Understanding torsade de pointes (TdP)/QT prolongation with different ChEIs is essential for …

Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering
from Alzheimer's disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or …

Inhibition of the cardiac human ether-a-go-go-related gene channel is a problematic off-
target pharmacological activity and, hence, a major safety liability in clinical practice. Several …