The endocannabinoid system (ECS) has been shown to be of great importance in the
regulation of numerous physiological and pathological processes. To date, two Class A G …

G protein‐coupled chemokine receptors and their peptidergic ligands are interesting
therapeutic targets due to their involvement in various immune‐related diseases, including …

Diversion of synthetic cannabinoids for abuse began in the early 2000s. Despite legislation
banning compounds currently on the drug market, illicit manufacturers continue to release …

G-protein-coupled receptors (GPCRs) represent the largest family of membrane proteins
involved in cellular signal transduction and are activated by various different ligand types …

Synthetic indole-derived cannabinoids have become commonly used recreational drugs
and continue to be abused despite their adverse consequences. As compounds that were …

The genesis of designing bivalent or bitopic molecules that engender unique
pharmacological properties began with Portoghese's work directed toward opioid receptors …

Specifically designed bivalent ligands targeting G protein‐coupled receptor (GPCR) dimeric
structures have become increasingly popular in recent literature. The advantages of the …

In the past decade, the world has experienced a large increase in the number of novel
compounds appearing on the illicit drug market for recreational purposes. Such substances …

In this mini-review, we summarize recent discoveries and present new hypotheses on the
role of cannabinoids in controlling trigeminal nociceptive system underlying migraine pain …

Nowadays, the increasing of multidrug-resistant pathogenic bacteria represents a serious
threat to public health, and the lack of new antibiotics is becoming a global emergency …