Targeting malaria parasites inside mosquitoes: ecoevolutionary consequences

T Kamiya, DG Paton, F Catteruccia, SE Reece - Trends in parasitology, 2022 - cell.com
Proof-of-concept studies demonstrate that antimalarial drugs designed for human treatment
can also be applied to mosquitoes to interrupt malaria transmission. Deploying a new …

Vector control: agents of selection on malaria parasites?

CE Oke, VA Ingham, CA Walling, SE Reece - Trends in Parasitology, 2022 - cell.com
Insect vectors are responsible for spreading many infectious diseases, yet interactions
between pathogens/parasites and insect vectors remain poorly understood. Filling this …

Investigating the dose-dependency of the midgut escape barrier using a mechanistic model of within-mosquito dengue virus population dynamics

RM Johnson, IJ Stopard, HM Byrne… - PLoS …, 2024 - journals.plos.org
Arboviruses can emerge rapidly and cause explosive epidemics of severe disease. Some of
the most epidemiologically important arboviruses, including dengue virus (DENV), Zika virus …

Estimating the extrinsic incubation period of malaria using a mechanistic model of sporogony

IJ Stopard, TS Churcher, B Lambert - PLoS computational biology, 2021 - journals.plos.org
During sporogony, malaria-causing parasites infect a mosquito, reproduce and migrate to
the mosquito salivary glands where they can be transmitted the next time blood feeding …

Streamlining sporozoite isolation from mosquitoes by leveraging the dynamics of migration to the salivary glands

AK Pathak, JC Shiau, B Franke-Fayard… - Malaria Journal, 2022 - Springer
Background Sporozoites isolated from the salivary glands of Plasmodium-infected
mosquitoes are a prerequisite for several basic and pre-clinical applications. Although …

Omitting age-dependent mosquito mortality in malaria models underestimates the effectiveness of insecticide-treated nets

MA Iacovidou, P Barreaux, SEF Spencer… - PLoS Computational …, 2022 - journals.plos.org
Mathematical models of vector-borne infections, including malaria, often assume age-
independent mortality rates of vectors, despite evidence that many insects senesce. In this …

Bluetongue research at a crossroads: Modern genomics tools can pave the way to new insights

J Kopanke, M Carpenter, J Lee, K Reed… - Annual Review of …, 2022 - annualreviews.org
Bluetongue virus (BTV) is an arthropod-borne, segmented double-stranded RNA virus that
can cause severe disease in both wild and domestic ruminants. BTV evolves via several key …

Time-and tissue-specific antimicrobial activity of the common bed bug in response to blood feeding and immune activation by bacterial injection

S Meraj, E Mohr, N Ketabchi, A Bogdanovic… - Journal of Insect …, 2021 - Elsevier
Unlike almost all hematophagous insects, common bed bugs, Cimex lectularius, are not
known to transmit pathogens to humans. To help unravel the reasons for their lack of vector …

The influence of oviposition status on measures of transmission potential in malaria-infected mosquitoes depends on sugar availability

JC Shiau, N Garcia-Diaz, DE Kyle, AK Pathak - Parasites & Vectors, 2024 - Springer
Background Like other oviparous organisms, the gonotrophic cycle of mosquitoes is not
complete until they have selected a suitable habitat to oviposit. In addition to the …

Testing a non-destructive assay to track Plasmodium sporozoites in mosquitoes over time

CE Oke, SE Reece, P Schneider - Parasites & Vectors, 2023 - Springer
Background The extrinsic incubation period (EIP), defined as the time it takes for malaria
parasites in a mosquito to become infectious to a vertebrate host, is one of the most …