Modified polynucleotides for reducing off-target effects in RNA interference
D Leake, A Reynolds, A Khvorova, W Marshall… - US Patent …, 2009 - Google Patents
Methods and compositions for performing RNA interference with decreased off-target effects
are provided The methods and compositions permit effective and efficient applications of …
are provided The methods and compositions permit effective and efficient applications of …
Oligoribonucleotides and ribonucleases for cleaving RNA
ST Crooke - US Patent 7,695,902, 2010 - Google Patents
Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are
provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate …
provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate …
Compositions and methods for inhibiting expression of Huntingtin gene
DWY Sah, P Hadwiger, I Roehl, B Bramlage… - US Patent …, 2008 - Google Patents
2007-01-12 Assigned to ALNYLAM EUROPE AG reassignment ALNYLAM EUROPE AG
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …
Double-stranded ribonucleic acid with increased effectiveness in an organism
C Woppmann, HP Vornlocher, P Hadwiger, M John… - 2005 - Google Patents
C12N15/113—Non-coding nucleic acids modulating the expression of genes, eg antisense
oligonucleotides; Antisense DNA or RNA; Triplex-forming oligonucleotides; Catalytic nucleic …
oligonucleotides; Antisense DNA or RNA; Triplex-forming oligonucleotides; Catalytic nucleic …
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
C Allerson, B Bhat, AB Eldrup, M Manoharan… - US Patent …, 2015 - Google Patents
The present invention provides compositions comprising at least one oligomeric compound
comprising an alternating motif and further include a region that is complementary to a …
comprising an alternating motif and further include a region that is complementary to a …
Oligonucleotides conjugated to protein-binding drugs
M Manoharan - US Patent 6,656,730, 2003 - Google Patents
The present invention relates to ligand-conjugated oligo meric compounds which bind to
protein molecules and possess enhanced pharmacokinetic properties. The present …
protein molecules and possess enhanced pharmacokinetic properties. The present …
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
C Allerson, B Bhat, AB Eldrup, M Manoharan… - US Patent …, 2013 - Google Patents
2004-05-18 Assigned to ISIS PHARMACEUTICALS, INC. reassignment ISIS
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
Positionally modified siRNA constructs
B Bhat, EE Swayze, TP Prakash, C Allerson… - US Patent …, 2013 - Google Patents
The present invention provides oligomeric compounds hav ing su? icient complementarity to
hybridize to a nucleic acid target and methods for their use in modulating gene expres sion …
hybridize to a nucleic acid target and methods for their use in modulating gene expres sion …
Chiral control
D Butler, N Iwamoto, N Svrzikapa, GL Verdine… - US Patent …, 2018 - Google Patents
The present invention relates to chirally controlled oligonucleotides, chirally controlled
oligonucleotide compositions, and the method of making and using the same. The invention …
oligonucleotide compositions, and the method of making and using the same. The invention …
Compositions and methods for inhibiting expression of Nav1. 8 gene
D Sah, M Frank-Kamenetsky, A Geick… - US Patent …, 2009 - Google Patents
2007-01-12 Assigned to ALNYLAM EUROPE AG reassignment ALNYLAM EUROPE AG
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …