Dynamic treatment regimes

B Chakraborty, SA Murphy - Annual review of statistics and its …, 2014 - annualreviews.org
A dynamic treatment regime consists of a sequence of decision rules, one per stage of
intervention, that dictate how to individualize treatments to patients, based on evolving …

[HTML][HTML] Dynamic treatment regimes: Technical challenges and applications

EB Laber, DJ Lizotte, M Qian, WE Pelham… - Electronic journal of …, 2014 - ncbi.nlm.nih.gov
Dynamic treatment regimes are of growing interest across the clinical sciences because
these regimes provide one way to operationalize and thus inform sequential personalized …

Statistical methods for dynamic treatment regimes

B Chakraborty, EE Moodie - Springer-Verlag. doi, 2013 - Springer
This book was written to summarize and describe the state of the art of statistical methods
developed to address questions of estimation and inference for dynamic treatment regimes …

Introduction to SMART designs for the development of adaptive interventions: with application to weight loss research

D Almirall, I Nahum-Shani… - Translational …, 2014 - academic.oup.com
The management of many health disorders often entails a sequential, individualized
approach whereby treatment is adapted and readapted over time in response to the specific …

New statistical learning methods for estimating optimal dynamic treatment regimes

YQ Zhao, D Zeng, EB Laber… - Journal of the American …, 2015 - Taylor & Francis
Dynamic treatment regimes (DTRs) are sequential decision rules for individual patients that
can adapt over time to an evolving illness. The goal is to accommodate heterogeneity …

[HTML][HTML] Q-and A-learning methods for estimating optimal dynamic treatment regimes

PJ Schulte, AA Tsiatis, EB Laber… - Statistical science: a …, 2014 - ncbi.nlm.nih.gov
In clinical practice, physicians make a series of treatment decisions over the course of a
patient's disease based on his/her baseline and evolving characteristics. A dynamic …

Informing sequential clinical decision-making through reinforcement learning: an empirical study

SM Shortreed, E Laber, DJ Lizotte, TS Stroup… - Machine learning, 2011 - Springer
This paper highlights the role that reinforcement learning can play in the optimization of
treatment policies for chronic illnesses. Before applying any off-the-shelf reinforcement …

[HTML][HTML] Q-learning with censored data

Y Goldberg, MR Kosorok - Annals of statistics, 2012 - ncbi.nlm.nih.gov
We develop methodology for a multistage-decision problem with flexible number of stages in
which the rewards are survival times that are subject to censoring. We present a novel Q …

Inference for Optimal Dynamic Treatment Regimes Using an Adaptive m-Out-of-n Bootstrap Scheme

B Chakraborty, EB Laber, Y Zhao - Biometrics, 2013 - academic.oup.com
A dynamic treatment regime consists of a set of decision rules that dictate how to
individualize treatment to patients based on available treatment and covariate history. A …

Q‐learning for estimating optimal dynamic treatment rules from observational data

EEM Moodie, B Chakraborty… - Canadian Journal of …, 2012 - Wiley Online Library
The area of dynamic treatment regimes (DTR) aims to make inference about adaptive,
multistage decision‐making in clinical practice. A DTR is a set of decision rules, one per …