Immunization is a cornerstone of public health policy and is demonstrably highly cost-
effective when used to protect child health. Although it could be argued that immunology has …

Polysaccharide-encapsulated organisms are the leading cause of bacterial meningitis and
pneumonia in children. The use of protein–polysaccharide conjugate vaccines in developed …

The insulin receptor substrate-1 (IRS-1), a docking protein for both the type 1 insulin-like
growth factor receptor (IGF-IR) and the insulin receptor, is known to send a mitogenic, anti …

Neisseria meningitidis remains a leading cause of meningitis and sepsis. This review
provides an update on our understanding of immunity against meningococcal infection …

Introduction: Glycoconjugate vaccines are among the safest and most efficacious vaccines
developed during the last 30 years. They are a potent tool for prevention of life-threatening …

Currently licensed glycoconjugate vaccines are composed of a carbohydrate moiety
covalently linked to a protein carrier. Polysaccharides are T-cell independent antigens able …

Glycoconjugate vaccines are among the most effective interventions for preventing several
serious infectious diseases. Covalent linkage of the bacterial capsular polysaccharide to a …

In 2005, two tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap)
vaccines were licensed and recommended for use in adults and adolescents in the United …

Glycoconjugate vaccines have proven their worth in the protection and prevention of
infectious diseases. The introduction of the Haemophilus influenzae type b vaccine is the …

Vaccination is a key strategy for the control of various infectious diseases. Many pathogens,
such as Streptococcus pneumoniae, Haemophilus influenzae type b (Hib), and Neisseria …