MicroRNAs as regulators of metabolic disease: pathophysiologic significance and emerging role as biomarkers and therapeutics

JA Deiuliis - International journal of obesity, 2016 - nature.com
The prevalence of overweight and obesity in developed and developing countries has
greatly increased the risk of insulin resistance and type 2 diabetes mellitus. It is evident from …

Role of miRNAs in the pathogenesis of T2DM, insulin secretion, insulin resistance, and β cell dysfunction: the story so far

P Kaur, S Kotru, S Singh, BS Behera… - Journal of physiology and …, 2020 - Springer
Diabetes, the most common endocrine disorder, also known as a silent killer disease, is
characterized by uncontrolled hyperglycemia. According to the International Diabetes …

Hepatic exosome-derived miR-130a-3p attenuates glucose intolerance via suppressing PHLPP2 gene in adipocyte

J Wu, T Dong, T Chen, J Sun, J Luo, J He, L Wei… - Metabolism, 2020 - Elsevier
Objective Glucose and lipid metabolism disorders are a major risk factor for type II diabetes
and cardiovascular diseases. Evidence has indicated that the interplay between the liver …

MiR-155 enhances insulin sensitivity by coordinated regulation of multiple genes in mice

X Lin, Y Qin, J Jia, T Lin, X Lin, L Chen, H Zeng… - PLoS …, 2016 - journals.plos.org
miR-155 plays critical roles in numerous physiological and pathological processes,
however, its function in the regulation of blood glucose homeostasis and insulin sensitivity …

Metformin reduces the senescence of renal tubular epithelial cells in diabetic nephropathy via the MBNL1/miR‐130a‐3p/STAT3 pathway

X Jiang, X Ruan, Y Xue, S Yang… - … medicine and cellular …, 2020 - Wiley Online Library
Senescence of renal tubular epithelial cells plays an important role in diabetic nephropathy,
but the mechanism is unknown. Metformin may alleviate diabetic nephropathy by reducing …

Exosomal miR‐130a‐3p regulates osteogenic differentiation of Human Adipose‐Derived stem cells through mediating SIRT7/Wnt/β‐catenin axis

S Yang, S Guo, S Tong, X Sun - Cell Proliferation, 2020 - Wiley Online Library
Objectives It is of profound significance for clinical bone regeneration to clarify the specific
molecular mechanism from which we found that osteogenic differentiation of adipose …

Triclosan-induced abnormal expression of miR-30b regulates fto-mediated m6A methylation level to cause lipid metabolism disorder in zebrafish

L Sun, M Gao, Q Qian, Z Guo, P Zhu, X Wang… - Science of the Total …, 2021 - Elsevier
Chronic exposure of triclosan (TCS) to zebrafish triggers high incidence of fatty liver and
hepatitis; however, the underlying molecular mechanisms remain unclear. Herein, we …

Cellular microRNA networks regulate host dependency of hepatitis C virus infection

Q Li, B Lowey, C Sodroski, S Krishnamurthy… - Nature …, 2017 - nature.com
Cellular microRNAs (miRNAs) have been shown to regulate hepatitis C virus (HCV)
replication, yet a systematic interrogation of the repertoire of miRNAs impacting HCV life …

LncRNA MEG8 attenuates cerebral ischemia after ischemic stroke through targeting miR-130a-5p/VEGFA signaling

S Sui, L Sun, W Zhang, J Li, J Han, J Zheng… - Cellular and molecular …, 2021 - Springer
MEG8 is involved in ischemia stroke, however, its role in ischemia stroke remains unknown.
The current research aimed to investigate the effects and mechanisms of MEG8 in ischemic …

Upregulation of miR-125b by estrogen protects against non-alcoholic fatty liver in female mice

ZC Zhang, Y Liu, LL Xiao, SF Li, JH Jiang, Y Zhao… - Journal of …, 2015 - Elsevier
Background & Aims Due to the protective effect of estrogen against hepatic fat accumulation,
the prevalence of non-alcoholic fatty liver disease (NAFLD) in premenopausal women is …