Critical assessment of phenotyping cocktails for clinical use in an African context

M Leuschner, AD Cromarty - Journal of Personalized Medicine, 2023 - mdpi.com
Interethnic and interindividual variability in in vivo cytochrome P450 (CYP450)-dependent
metabolism and altered drug absorption via expressed transport channels such as P …

The importance of tailoring drug treatment to ensure safe and effective treatment in a diverse South African population

M Leuschner - South African General Practitioner, 2021 - journals.co.za
Personalised medicine ensures individualised treatment regimens in order to minimise
medicine adverse reactions, medicine interactions and optimise therapeutic outcomes. In …

Assessing Inter-Method Agreement of Drug-Based Phenotyping Metrics Between Dried Blood Spot and Plasma Sampling

M Leuschner - 2019 - search.proquest.com
Introduction: Pharmacokinetic variability in response to pharmacotherapy contribute to
adverse drug reactions, drug-drug interaction and therapeutic failure seen in clinical …