Due to the pharmacological activities of quinazoline and quinazolinone scaffolds, it has
aroused great interest in medicinal chemists for the development of new drugs or drug …

Due to the complexity of multifactorial diseases, single-target drugs do not always exhibit
satisfactory efficacy. Recently, increasing evidence indicates that simultaneous modulation …

Cancer is a leading cause of death and a major health problem worldwide. While many
effective anticancer agents are available, the majority of drugs currently on the market are …

In this study, novel quinazolinone derivatives 7a-n were synthesized and evaluated against
metabolic enzymes including α-glycosidase, acetylcholinesterase, butyrylcholinesterase …

Cancer diseases remain major health problems in the world despite significant
developments in diagnostic methods and medications. Many of the conventional therapies …

While elemental sulfur has been largely used as oxidant or sulfurating agent, its role as a
catalyst has not been developed. We report here its catalytic activity in the oxidative …

Heterocycles and their derivatives have been inspiring medicinal chemists to device novel,
greener and efficient ways to synthesized them as the majority of drugs available in the …

Quinazolines represent a class of nitrogen-containing heterocyclics with a broad spectrum of
biological applications. Many studies have explored the medicinal qualities of quinazoline …

Background Rhodanines and quinazolinones have been reported to possess various
pharmacological activities. Results A novel series of twenty quinazolinone-based …

Herein, we describe an efficient method involving the synthesis of diverse quinoxalines
using the DMSO/tBuONa/O2 system as a single-electron oxidant to form α-imino radicals …