The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …
expression programmes. Significant advances have been made in understanding the …
Hypoxia and the extracellular matrix: drivers of tumour metastasis
Of the deaths attributed to cancer, 90% are due to metastasis, and treatments that prevent or
cure metastasis remain elusive. Emerging data indicate that hypoxia and the extracellular …
cure metastasis remain elusive. Emerging data indicate that hypoxia and the extracellular …
Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia
FTO, an mRNA N 6-methyladenosine (m 6 A) demethylase, was reported to promote
leukemogenesis. Using structure-based rational design, we have developed two promising …
leukemogenesis. Using structure-based rational design, we have developed two promising …
Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5
Y Huang, J Yan, Q Li, J Li, S Gong, H Zhou… - Nucleic acids …, 2015 - academic.oup.com
Two human demethylases, the fat mass and obesity-associated (FTO) enzyme and ALKBH5,
oxidatively demethylate abundant N 6-methyladenosine (m6A) residues in mRNA …
oxidatively demethylate abundant N 6-methyladenosine (m6A) residues in mRNA …
Targeting metalloenzymes for therapeutic intervention
AY Chen, RN Adamek, BL Dick, CV Credille… - Chemical …, 2018 - ACS Publications
Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …
2-Oxoglutarate-dependent oxygenases
MS Islam, TM Leissing, R Chowdhury… - Annual review of …, 2018 - annualreviews.org
2-Oxoglutarate (2OG)-dependent oxygenases (2OGXs) catalyze a remarkably diverse range
of oxidative reactions. In animals, these comprise hydroxylations and N-demethylations …
of oxidative reactions. In animals, these comprise hydroxylations and N-demethylations …
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
Two Krebs cycle genes, fumarate hydratase (FH) and succinate dehydrogenase (SDH), are
mutated in a subset of human cancers, leading to accumulation of their substrates, fumarate …
mutated in a subset of human cancers, leading to accumulation of their substrates, fumarate …
Catalytic mechanisms of Fe (II)-and 2-oxoglutarate-dependent oxygenases
S Martinez, RP Hausinger - Journal of Biological Chemistry, 2015 - ASBMB
Mononuclear non-heme Fe (II)-and 2-oxoglutarate (2OG)-dependent oxygenases comprise
a large family of enzymes that utilize an Fe (IV)-oxo intermediate to initiate diverse oxidative …
a large family of enzymes that utilize an Fe (IV)-oxo intermediate to initiate diverse oxidative …
RNA methylations in human cancers
RNA methylations, as the prevalent post-transcriptional modifications, are critical in
regulating various biological processes, such as RNA transcription, splicing, structure …
regulating various biological processes, such as RNA transcription, splicing, structure …
Mitochondrial complex II: at the crossroads
Mitochondrial complex II (CII), also called succinate dehydrogenase (SDH), is a central
purveyor of the reprogramming of metabolic and respiratory adaptation in response to …
purveyor of the reprogramming of metabolic and respiratory adaptation in response to …